Angiotensin I-Converting Enzyme Inhibitory Activity of the C-Terminal Hexapeptide of αs1-Casein
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概要
- 論文の詳細を見る
Thr-Thr-Met-Pro-Leu-Trp, the C-terminal hexapeptide of αs1-casein, inhibited the angiotensin I-converting enzyme (I50 = 16 μM). Z-Pro-Leu-Trp also inhibited the enzyme (I50 = 18μM). The Pro-Leu-Trp sequence may be important for the inhibitory activity of this hexapeptide. Z-Pro-Val-Trp, which contains Val in place of Leu, inhibited the enzyme more potently (I50=2.9μM). The antihypertensive activity of this hexapeptide was also investigated. This peptide, when intravenously administered to anesthetized rats at 31.8mg/kg, tended to antagonize the rats pressor response to angiotensin I.
- 社団法人 日本農芸化学会の論文
著者
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Kurono Masayasu
Sanwa Kagaku Kenkyusho Co. Ltd.
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Tomizuka Noboru
Fermentation Research Institute
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Maruyama Susumu
Fermentation Research Institute
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SUZUKI Hideo
Fermentation Research Institute
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KURONO Masayasu
Sanwakagaku Kenkyusho Co., Ltd.
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AWAYA Juichi
Sanwakagaku Kenkyusho Co., Ltd.
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MITACHI Hajime
Sanwakagaku Kenkyusho Co., Ltd.
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