Prolylendopeptidase Inhibitory Activity of a Glial Fibrillary Acidic Protein Fragment and Other Proline-rich Peptides
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概要
- 論文の詳細を見る
The brain prolylendopeptidase (PEP) inhibitory activity of syn-thetic peptides related to the bovine brain-derived PEP inhibitor, GFAP-(38-55) (MPPPLPARVDFSLAGALN), was investigated. Homologous peptides such as MPPPLPTRVDFSLAGALN (human type) and MTPPLPARVDFSLAGALN (mouse type) also inhibited PEP. Among various synthetic fragments of GFAP-(38-55), only MPPPLP had a K_i essentially the same as that of GFAP-(38-55). Similar synthetic proline-rich peptides such as synapsin fragments and SH3 domain-binding peptides had more or less inhibitory activity.
- 社団法人日本農芸化学会の論文
- 1996-02-23
著者
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Maruyama Susumu
Fermentation Research Institute
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Maruyama Susumu
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
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Maruyama Susumu
National Institute Of Bioscience And Human Technology Agency Of Industrial Science And Technology
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Ohmori Takashi
Department of Health and Dietary Science, Research and Development Center, Nippon Meat Packers, Inc.
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Ohmori Takashi
Department Of Health And Dietary Science Research And Development Center Nippon Meat Packers Inc.
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NAKAGAMI Tatsuyoshi
Department of Health and Dietary Science, Research and Development Center, Nippon Meat Packers, Inc.
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OHMORI Takashi
Research and Development Center, Nippon Meat Packers, Inc.
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NAKAGAMI Tatsuyoshi
Research and Development Center, Nippon Meat Packers, Inc.
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Nakagami Tatsuyoshi
Department Of Health And Dietary Science Research And Development Center Nippon Meat Packers Inc.
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Ohmori Takashi
Research And Development Center Nippon Meat Packers Inc.
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