Angiotensin I-Converting Enzyme Inhibitory Activities of Synthetic Peptides Related to the Tandem Repeated Sequence of a Maize Endosperm Protein(Food & Nutrition)
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概要
- 論文の詳細を見る
Peptides that exist in the tandem repeated region formed by six units of Pro-Pro-Pro-Val-His-Leu in a maize endosperm protein γ-zein were chemically synthesized, and the angiotensin I-converting enzyme inhibitory activities of these peptides were investigated. Synthetic Val-His-Leu-Pro-Pro-Pro inhibited the enzyme (IC_<50>=200 μM). Other synthetic fragment peptides, Val-His-Leu-Pro-Pro (IC_<50>=18 μM) and Leu-Pro-Pro (IC_<50>=9.6 μM) inhibited the enzyme more potently. Then the native hexapeptide Val-His-Leu-Pro-Pro-Pro was purified from a thermolysin hydrolysate of γ-zein. The antihypertensive activities of synthetic Val-His-Leu-Pro-Pro and Leu-Pro-Pro were also investigated. These peptides, when intravenously administered to anesthetized rats at 125 mg/kg (Leu-Pro-Pro) or 160 mg/kg (Val-His-Leu-Pro-Pro), antagonized the rats' pressor response to angiotensin I.
- 社団法人日本農芸化学会の論文
- 1989-04-23
著者
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Kaneko Tetsuya
Laboratory Of Biochemistry And Nutritional Chemistry Faculty Of Agriculture Kagoshima University
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Maruyama Susumu
Fermentation Research Institute
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Maruyama Susumu
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
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Maruyama Susumu
National Institute Of Bioscience And Human Technology Agency Of Industrial Science And Technology
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Kaneko T
Research And Development Center Showa Sangyo Co. Ltd.
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TANAKA Hideoki
Fermentation Research Institute
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MIYOSHI Shinsuke
Central Research Laboratories, Showa Sangyo Co., Ltd.
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KANEKO Toshiyuki
Central Research Laboratories, Showa Sangyo Co., Ltd.
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Tanaka Hideoki
National Institute Of Bioscience And Human-technology Agency Of Industrial Science And Technology
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Miyoshi S
Showa Sangyo Co. Ltd. Ibaraki Prefecture Jpn
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