Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Orally administered methanol extract of Passiflora edulis rind (10 mg/kg or 50 mg/kg) or luteolin (50 mg/kg), which is one of consistent polyphenols of the extract, significantly lowered systolic blood pressure in spontaneously hypertensive rats (SHRs). Quantitative analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) showed that the extract contained 20 μg/g dry weight of luteolin and 41 μg/g dry weight of luteolin-6-C-glucoside. It also contained γ-aminobutyric acid (GABA, 2.4 mg/g dry weight by LC-MS/MS or 4.4 mg/g dry weight by amino acid analysis) which has been reported to be an antihypertensive material. Since the extract contained a relatively high concentration of GABA, the antihypertensive effect of the extract in SHRs might be due mostly to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin.
- 社団法人 日本農芸化学会の論文
- 2006-03-23
著者
-
Kamada Yasuhiro
Okinawa Industrial Technology Center
-
ICHIBA Toshio
Okinawa Ind. Tech. Center
-
Ichimura Toshiaki
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science
-
Yamanaka Akiko
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science
-
MARUYAMA Susumu
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science
-
TOYOKAWA Tetsuya
Okinawa Industrial Technology Center
-
TAMAMURA Takako
Okinawa Industrial Technology Center
-
Maruyama Susumu
Fermentation Research Institute
-
Maruyama Susumu
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
-
Maruyama Susumu
National Institute Of Bioscience And Human Technology Agency Of Industrial Science And Technology
-
Ichimura Toshiaki
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
-
Ichimura T
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
-
Yamanaka Akiko
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
関連論文
- 1Ip21 Production of (R)-3HB by Azohydromonas lata with low-cost raw materials
- Antihypertensive Effect of Enzymatic Hydrolysate of Collagen and Gly-Pro in Spontaneously Hypertensive Rats
- Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats
- Luteolin Inhibits Endothelin-1 Secretion in Cultured Endothelial Cells
- A Synthetic Polymer, Poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate), Stimulated Insulin Release from RINm5F Insulinoma Cells
- Angiotensin I-Converting Enzyme Inhibitory Activity and Insulin Secretion Stimulative Activity of Fermented Fish Sauce
- 2P-2077 Fermentation and Bioconversion Processes for Production of (R)-3-hydroxybutyric acid
- Hypotensive Activity of Enzymatic α-Zein Hydrolysate(Biological Chemistry)
- Structures and Activity of Angiotensin-converting Enzyme Inhibitors in an α-Zein Hydrolysate(Biological Chemistry)
- Angiotensin I-Converting Enzyme Inhibitory Activities of Synthetic Peptides Related to the Tandem Repeated Sequence of a Maize Endosperm Protein(Food & Nutrition)
- Aminopeptidase P, Capable of Hydrolyzing Oligoproline, from Bovine Brain
- Inhibition of HIV-1 Protease by Water-Soluble Lignin-Like Substance from an Edible Mushroom, Fuscoporia obliqua
- Evaluation of Antioxidant Activity of Vegetables from Okinawa Prefecture and Determination of Some Antioxidative Compounds
- New Phenolic Compounds from Kokuto, Non-centrifuged Cane Sugar(Organic Chemistry)
- New Antioxidative Phenolic Glycosides Isolated from Kokuto Non-centrifuged Cane Sugar(Organic Chemistry)
- Free Radical Scavenging and Hepatoprotective Actions of the Medicinal Herb, Crassocephalum crepidioides from the Okinawa Islands(Biochemistry/Molecular Biology)
- Antihypertensive Effect of Enzymatic Hydrolysate of Collagen and Gly-Pro in Spontaneously Hypertensive Rats
- In Vitro and in Vivo Anti-platelet Effects of Enzymatic Hydrolysates of Collagen and Collagen-related Peptides
- Prolylendopeptidase Inhibitory Activity of a Glial Fibrillary Acidic Protein Fragment and Other Proline-rich Peptides
- Prolyl Endopeptidase Inhibitory Activity of Peptides in the Repeated Sequence of Various Proline-Rich Proteins
- Angiotensin I-Converting Enzyme Inhibitors Derived from Ficus carica(Biological Chemistry)
- HIV-1 Protease Inhibition and Anti-HIV Effect of Natural and Synthetic Water-soluble Lignin-like Substances
- Purification of angiotensin I-converting enzyme inhibitors in pelagic thresher Alopias pelagicus muscle hydrolysate and viscera extracts
- 1Bp12 Influence of bioconversion process with Azohydromonas lata on the resting cells, production of (R)-3-hydroxybutyric acid and poly(3-hydroxybutyrate)
- Angiotensin I-Converting Enzyme Inhibitor Derived from an Enzymatic Hydrolysate of Casein. II. Isolation and Bradykinin-potentiating Activity on the Uterus and the Ileum of Rats
- Studies on the Active Site and Antihypertensive Activity of Angiotensin I-Converting Enzyme Inhibitors Derived from Casein
- Angiotensin I-Converting Enzyme Inhibitory Activity of the C-Terminal Hexapeptide of αs1-Casein
- A Peptide Inhibitor of Angiotensin I Converting Enzyme in the Tryptic Hydrolysate of Casein