Free Radical Scavenging and Hepatoprotective Actions of the Medicinal Herb, Crassocephalum crepidioides from the Okinawa Islands(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
Free radical scavenging and protective actions against chemically induced hepatotoxicity of Crassocephalum crepidioides were investigated. A water extract of C. crepidioides strongly scavenged superoxide anion, hydroxyl radical and also stable radical 1, 1-diphenyl-2-picrylhydrazyl. Galactosamine (GalN, 400mg/kg) and lipopolysaccharide (LPS, 0.5 μg/kg) induced hepatotoxicity of rats as seen by an elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and of lipid peroxidation in liver homogenates was significantly depressed when the herbal extract was given intraperitoneally 1 and 15 h before GalN and LPS treatment. Similarly, carbon tetrachloride (CCl_4) induced liver injury as evidenced by an increase in AST and ALT activities in serum was also inhibited by the extract pretreatment. Isochlorogenic acids, quercetin and kaempferol glycosides were identified as active components of C. crepidioides with strong free radical scavenging action. These results demonstrate that C. crepidioides is a potent antioxidant and protective against GalN plus LPS- or CCl_4-induced hepatotoxicity.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
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Koyama Tomoyuki
Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Tec
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Aniya Yoko
Laboratory of Molecular Genetics and Pharmacology, School of Health Sciences, Faculty of Medicine, U
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Aniya Y
Univ. Ryukyus Okinawa Jpn
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Aniya Yoko
Laboratory Of Functional And Molecular Pharmacology Graduate School Of Medicine University Of The Ry
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ICHIBA Toshio
Okinawa Ind. Tech. Center
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Ichiba Toshio
Okinawa Industrial Technology Center
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Ichiba Toshio
Exploratory Medicinal Sciences Pfizer Global Research And Development(pgrd)-nagoya Laboratories Pfiz
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Koyama T
Shinshu Univ. Nagano Jpn
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Koyama Tomoyuki
Laboratory Of Nutraceuticals And Functional Foods Science Graduate School Of Marine Science And Tech
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MIYAGI Chika
Department of Laboratory Medicine, Faculty of Medicine, University of the Ryukyus
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MIYAHIRA Manami
Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus
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INOMATA Chiho
Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus
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KINOSHITA Shizuka
Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus
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Miyagi C
Univ. Ryukyus Okinawa Jpn
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Inomata Chiho
Laboratory Of Molecular Pharmacology Graduate School Of Medicine University Of The Ryukyus
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Miyahira Manami
Laboratory Of Molecular Pharmacology Graduate School Of Medicine University Of The Ryukyus
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Aniya Yoko
琉球大学 保健
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MIYAGI Chika
Department of Biological Resource Sciences, Faculty of Agriculture
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