Protective Effect of the Mold Monascus Anka Against Acetaminophen-Induced Liver Toxicity in Rats
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概要
- 論文の詳細を見る
Antioxidant and hepatoprotective actions of the mold Monascus anka (also called Beni-Koji in Japan) against acetaminophen (AAP)-induced liver toxicity were investigated. Serum aspartate aminotransferase and glutathione S-transferase (GST) activities increased by AAP (180 mg/kg, i.p.) treatment were depressed when the Beni-Koji preparation (4 ml/kg, i.p.) was given 15 and 1 hr before AAP administration. The decrease in liver cytosolic GST activity by AAP, reflecting the release of the enzyme into serum, was also blocked by the mold. Cytochrome P450 activity was inhibited by the Beni-Koji preparation. These results suggest that M. anka prevents AAP-induced liver toxicity by both antioxidant action and the inhibition of AAP metabolism.
- 社団法人 日本薬理学会の論文
著者
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Aniya Yoko
Laboratory of Molecular Genetics and Pharmacology, School of Health Sciences, Faculty of Medicine, U
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Aniya Y
Univ. Ryukyus Okinawa Jpn
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Aniya Yoko
Laboratory Of Functional And Molecular Pharmacology Graduate School Of Medicine University Of The Ry
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Aniya Yoko
琉球大学 保健
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YOKOMAKURA Takahiro
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, Universit
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NAGAMINE Tatsumi
Clinical Laboratory of the University Hospital, Faculty of Medicine, University of the Ryukyus
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NAKANISHI Hisaharu
Tropical Technology Center Limited
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Nagamine T
Clinical Laboratory Of The University Hospital Faculty Of Medicine University Of The Ryukyus
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Yokomakura Takahiro
Laboratory Of Physiology And Pharmacology School Of Health Sciences Faculty Of Medicine University O
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Yonamine Masato
Laboratory of Physiology and Pharmacology, School of Health Sciences, University of the Ryukyus
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