ENHANCEMENT OF HEPATIC MICROSOMAL ANILINE HYDROXYLATION BY HABU SNAKE (<I>Trimeresurus flavoviridis</I>) VENOM FRACTIONS
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概要
- 論文の詳細を見る
Enhancement of aniline hydroxylation by Habu snake venom was studied in vitro. The fraction which was isolated from Habu venom through column chromatography caused the enhancement of aniline hydroxylation of hepatic microsomes obtained from untreated rats. This fraction was heat stable and free from phospholipase activity. Enhancement of aniline hydroxylation was not clear in crude Habu venom or the unheated fraction, but appeared after heating of the fraction. This fraction enhanced aniline hydroxylation at low concentrations, followed by inhibition at high concentrations, but inhibited aminopyrine N-demethylation dose-dependently. Aniline hydroxylation was enhanced by the heated fraction at more than 1 mM aniline, and the enhancement was rather decreased at more than 10 mM aniline. The degree of the enhancement by the heated fraction increased with increasing pH.
- 社団法人 日本薬理学会の論文
著者
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Aniya Yoko
Laboratory of Molecular Genetics and Pharmacology, School of Health Sciences, Faculty of Medicine, U
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Aniya Yoko
Laboratory Of Functional And Molecular Pharmacology Graduate School Of Medicine University Of The Ry
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MATSUSAKI Kichihiko
Miyazaki Medical College
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ANIYA Yoko
Laboratory of Pharmacology and Toxicology, School of Health Sciences, University of the Ryukyus
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