SMOOTH MUSCLE CONTRACTILE ACTION OF THE VENOM FROM THE CROWN-OF-THORNS STARFISH, ACANTHASTER PLANCI
スポンサーリンク
概要
- 論文の詳細を見る
The fraction (venom B) of spine venom from the crown-of-thorns starfish (Acanthaster planci) caused contractions of the uterus of rats and enhanced vascular permeability in rabbits. The venom B-induced contraction of the smooth muscle was depressed by inhibitors of prostaglandin synthesis such as indomethacin or aspirin, but not by the anticholinergic agent, atropine. The fraction with the uterus contractile action was partially purified from venom B through column chromatography. This fraction contains phospholipase and proteinase activities and was different from the lethal factor in the venom. These results suggest that the uterine contractile action caused by venom B is mediated by prostaglandins and partly contributed by the activity of phospholipase in the venom.
- 日本トキシコロジー学会の論文
著者
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Aniya Yoko
Laboratory Of Functional And Molecular Pharmacology Graduate School Of Medicine University Of The Ry
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Aniya Yoko
琉球大学 医学研究科
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KARASUDANI Izuru
Laboratory of Physiology and Pharmacology, School of Health Sciences
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OMIJA Mayumi
Laboratory of Physiology and Pharmacology, School of Health Sciences
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Omija Mayumi
Laboratory Of Physiology And Pharmacology School Of Health Sciences
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Karasudani Izuru
Laboratory Of Physiology And Pharmacology School Of Health Sciences
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