Diurnal Variation and Increase of Disaccharidase Activity in Diabetic Rats.

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概要

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• The small intestinal disaccharidase activity and its daily variation in the diabetic rat have not been well described. Therefore, the small intestinal disaccharidase (maltase, lactase and sucrase) activity and its daily profile were studied in streptozotocin-induced diabetic rats under physiological conditions. In diabetic rats, a similar pattern of diurnal variation of disaccharidase activity to control rats was observed, while the relationships between daily change of disaccharidase activity and that of food consumption suggested that there was a different mechanism of diurnal variation in diabetic rats. On the other hand, a significant increase of mean 24-h lactase and sucrase activities was noted in diabetic rats, while that of maltase was not significant. Using the in vitro incubation method, a significant correlation between glucose concentration and lactase or sucrase activity but not maltase activity was observed. However, insulin showed no effect on disaccharidase activity. Thus we clarified the presence of a diurnal variation of disaccharidase activity and an increase in its activity in diabetic rats. This change was suggested to be derived from high plasma glucose level.

• 財団法人 学会誌刊行センターの論文

著者

• Mimura Goro

  Second Department Of Internal Medicine Ryukyu University

• NASHIRO Kazutaka

  Second Department of Internal Medicine, School of Medicine, University of the Ryukyus

• MURAKAMI Keiji

  Second Department of Internal Medicine, School of Medicine, University of the Ryukyus

• MURAKAMI Keiji

  Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus

• MIMURA Goro

  Second Department of Internal Medicine, School of Medicine, University of the Ryukyus

関連論文

• CHANGES OF SERUM TOTAL CHOLESTEROL AND TRIGLYCERIDE LEVELS IN NORMAL SUBJECTS IN JAPAN IN THE PAST TWENTY YEARS : Research Committee on Familial Hyperlipidemia in Japan
• Diurnal Variation and Increase of Disaccharidase Activity in Diabetic Rats.
• Chronic Effects of Tolbutamide on Myocardial Tension during Ischemia and Reperfusion in Perfused Hearts Isolated from Insulin Dependent and Non Insulin Dependent Diabetic Rats.
• Glutathione S-transferases and chloroform toxicity in streptozotocin-induced diabetic rats.

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