Syntheses of 2-Deoxy-2-[(2R,3S)-2-fluoro-3-hydroxytetradecanamido]-3-O-[(3R)-3-hy-droxytetradecanoyl]-4-O-phosphono-D-glucopyranose and Its (2S,3R)-Isomer
スポンサーリンク
概要
- 論文の詳細を見る
2-Deoxy-2- [(2R, 3S) -2-fluoro- 3-hydroxytetradecanamido ]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-D-glucopyranose and its (2S,3R)-isomer were respectively synthesized from allyl 2-[(2R, 3S)-3-(benzyloxycarbonyloxy)-2-fluorotetradecanamido]-2-deoxy-4, 6-O-isopropylidene-β-D-glucopyranoside and its corresponding (2S, 3R)-isomer. Both target compounds did not activate macrophage, but the (2S, 3R)-analogue strongly inhibited the binding of LPS to macrophage.
- 社団法人日本農芸化学会の論文
- 1993-09-23
著者
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Arai Masami
Exploratory Chemistry Research Laboratories Sankyo Co. Ltd.
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NISHIJIMA Masahiro
Department of Biochemistry and Cell Biology, National Institute of Health
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Hiraoka Tetsuo
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd.
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Akamatsu Yuzuru
Department of Biochemistry and Cell Biology, National lnstitute of Health
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Arai M
Exploratory Chemistry Research Laboratories Sankyo Co. Ltd.
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Arai M
Division Of Materials Science And Engineering Graduate School Of Engineering Hokkaido University
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Shiozaki M
Exploratory Chemistry Research Laboratories Sankyo Co. Ltd.
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Shiozaki Masao
New Lead Research Laboratories Sankyo Co. Ltd.
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Shiozaki Masao
Chemical Research Laboratories Sankyo Co. Ltd.
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Nishijima Masahiro
Department Of Biochemistry And Cell Biology National Institute Of Health
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Arai Masami
New Lead Research Laboratories, Sankyo Co., Ltd.
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Hiraoka Tetsuo
New Lead Research Laboratories, Sankyo Co., Ltd.
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Hiraoka Tetsuo
Exploratory Chemistry Research Laboratories Sankyo Co. Ltd.
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Akamatsu Yuzuru
Bioactive Molecules Research Group Microbial Chemistry Research Center
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