Synthesis of 2-amino-2-deoxy-.ALPHA.-D-altrofuranoside derivatives from 2,3-O-isopropylidene-D-glyceraldehyde via bicyclic .BETA.-lactam intermediates.
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概要
- 論文の詳細を見る
A bicyclic β-lactam (<B>4</B>), obtained from 2,3-<I>O</I>-isopropylidene-D-glyceraldehyde in 3 steps, was converted to methyl 2-benzamido-2-deoxy-5,6-<I>O</I>-isopropylidene-3-<I>O</I>-(3-chlorobenzoyl)-α-D-altrofuranoside (<B>24</B>) through an additional 8 steps by utilizing the β-lactam nitrogen via the oxidative decarboxylation of diacyl peroxide (<B>23</B>). Additionally, it was shown that the bicyclic β-lactam intermediate is a suitable precursor for 2-amino-3-(branched-chain)-2-deoxy-D-furanoside derivatives.
- 公益社団法人 日本化学会の論文
著者
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Shiozaki Masao
New Lead Research Laboratories Sankyo Co. Ltd.
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Sato Sadao
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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Ishida Noboru
New Lead Research Laboratories, Sankyo Co., Ltd.
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Shiozaki Masao
New Lead Research Laboratories, Sankyo Co., Ltd.
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