Simultaneous Evaluation of Gastric and Duodenal Ulcers-Healing Activities of Anti-ulcer Agents in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effects of cimetidine, omeprazole and atropine, antisecretory anti-ulcer agents, on the healing of gastric and duodenal ulcers simultaneously induced in the same rats. Furthermore, we examined the effect of histamine, an acid secretory agent, on the healing of both ulcers. When the effects of test drugs were assessed on the 15th day after local application of acetic acid, repeated oral administration of cimetidine (50 and 100 mg/kg twice daily) or omeprazole (25 and 50 mg/kg once daily) markedly accelerated the healing of both gastric and duodenal ulcers. Atropine (10 mg/kg twice daily, p.o.) showed a healing effect on duodenal ulcers only. The repeated subcutaneous administration of histamine (30 mg/kg 3 times daily) apparently delayed the healing of duodenal ulcers but not gastric ulcers. In conclusion, this experimental chronic ulcer model in rats is useful for directly comparing the effects of anti-ulcer drugs on the healing of gastric and duodenal ulcers. In addition, the increase in acid secretion appears to have a greater influence on the delay of ulcer healing in the duodenum than in the stomach.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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ITO Mikio
Department of Materials Science and Processing, Graduate School of Engineering, Osaka University
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Ito Mikio
三和化学研究所総合研究所
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Ito M
Meijo Univ. Nagoya Jpn
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Suzuki Y
Fukuoka Inst. Technol. Fukuoka
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Ito M
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Suzuki Y
Meijo Univ. Nagoya Jpn
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SUZUKI Yoshio
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Suzuki Y
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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ITO Mikio
Laboratory of Analytical Pharmacology, Faculty of Pharmacy, Meijo University
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Suzuki Y
Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph
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Suzuki Y
Faculty Of Pharmacy Meijo University
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SEGAMI Tetsuya
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Segami Tetsuya
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Ito Mikio
Department Of Materials Science And Processing Graduate School Of Engineering Osaka University
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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Ito Mikio
Department Of Analytical Pharmacology Faculty Of Pharmacy Meijo University
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