Caffeic Acid Oligomers with Hyaluronidase Inhibitory Activity from Clinopodium gracile

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概要

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• Eight new caffeic acid oligomers, clinopodic acids J–Q (1–8), were isolated from whole plants of Clinopodium gracile, together with nine known caffeic acid oligomers. The caffeic acid oligomers with two to four dihydrobenzofuran rings were isolated as natural products for the first time. Clinopodic acid M (4) showed the strongest hyaluronidase inhibitory activity, IC50 (19 µM) among the 22 compounds isolated from this plant.

著者

• Miyase Toshio

  School Of Pharmaceutical Science University Of Shizuoka

• Warashina Tsutomu

  Institute For Environmental Sciences University Of Shizuoka

• Aoshima Hiroaki

  School of Pharmaceutical Sciences, University of Shizuoka

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