Monoamine Oxidase Inhibitors from Cinchonae Cortex
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概要
- 論文の詳細を見る
Three strong alkaloidal monoamine oxidase (MAO) inhibitors, quinine (1), cinchonicinol ([1S, 3'R, 4'R]-3-(3-ethenyl-4-piperidinyl)-1-(4-quinolinyl)-1-propanol) (2) and cinchonaminone ([3'R, 4'S]-2-[2-(3-ethenyl-4-piperidinyl)-acetyl]-1H-indole-3-ethanol) (3), were isolated from Cinchonae Cortex (Cinchona succirubra PAV., Rubiaceae). The structures of 2 and 3 were elucidated on the bases of spectral data and chemical evidence, and 3 is a new alkaloid.The inhibitory effects on MAO of 1,2,3 and related alkaloids were assayed. The type of inhibition by 1 with respect to benzylamine as a substrate was competitive.
- 公益社団法人日本薬学会の論文
- 1989-02-25
著者
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黒柳 正典
静岡県大・薬
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上野 明
School Of Pharmaceutical Sciences University Of Shizuoka
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上野 明
Shizuoka College of Pharmacy
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宮瀬 敏男
Shizuoka College of Pharmacy
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黒柳 正典
Shizuoka College of Pharmacy
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野呂 忠敬
Shizuoka College of Pharmacy
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宮瀬 敏男
School Of Pharmaceutical Sciences University Of Shizuoka
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梅原 薫
School of Pharmaceutical Sciences, University of Shizuoka
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野呂 忠敬
School of Pharmaceutical Sciences, University of Shizuoka
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三井 直樹
Shizuoka College of Pharmacy
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梅原 薫
Shizuoka College of Pharmacy
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Miyake T
School Of Pharmaceutical Sciences University Of Shizuoka
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野呂 忠敬
School Of Pharmaceutical Sciences University Of Shizuoka
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Umehara K
School Of Pharmaceutical Sciences University Of Shizuoka
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梅原 薫
School Of Pharmaceutical Sciences University Of Shizuoka
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