常山の抗補体活性物質の研究。ステロイド誘導体の抗補体作用

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概要

• 論文の詳細を見る

• Methanol extracts of 53 crude drugs were tested on the anticomplementary activity. Of these, 12 samples showed the potent activity. Of these 12 samples, the extract of Jozann (Dichrome Radix) was studied on the isolation and structural elucidation of the anticomplementary constituents. As active constituents, 3β-hydroxystigmast-5-en-7-one was isolated and its structure was confirmed by deriving this compound from β-sitosterol. The activity of such steroid derivatives as stigmastane, cholestane, androstane and pregnane type steroids were further studied. Of these, several kinds of steroids showed the potent activity. From these experiments, the structure and activity relationship was discussed.

• 公益社団法人日本薬学会の論文
• 1991-06-25

著者

• 黒柳 正典

  静岡県大・薬

• 上野 明

  School Of Pharmaceutical Sciences University Of Shizuoka

• 海老原 毅

  静岡県立大学薬学部

• 上野 明

  静岡県立大学薬学部

• 福島 清吾

  静岡県立大学薬学部

• 黒柳 正典

  School Of Pharmaceutical Sciences University Of Shizuoka

• 黒柳 正典

  静岡県立大学薬学部

• 川合 智子

  静岡県立大学薬学部

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