56 Andrographis paniculataの細胞分化誘導物質の研究(ポスター発表の部)

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Recetly, much attention has been given to the subject of differentiation inducers as new types of anti-tumor substances. We studied the cell differentiation inducers of A. paniculata Nees (Acanthaceae). The methanol extract of the whole plant showed the differentiation inducing activity on mouse myeloid leukemia (M1) cells. From ethyl acetate soluble fraction of the extract, thirteen ent-labdan tyep diterpenoids containing six new compounds and three new dimers of diterpenoids were isolated. The structures of the diterpenoids were determined on the basis of spectral methods, such as ^1H-NMR, ^<13>C-NMR, H-H COSY, C-H COSY. Their structures were illustrated in Fig 1 and Fig 2. We tested the cell diferentiation inducing activity of these diterpenoids on the M1 cells. The inducibility of phagocytosis of the M1 cells was observed for the marker of the activity. As a result, aglycons of diterpenoids except for AP-6 showed the strong phagocytosis and growth inhibitory activity, whereas diterpenoid glucosides except for AP-13 did not show such activities. The dimers of diterpenoids also showed the strong phagocytosis. In order to investigate the structure-activity relationship, several kinds of derivatives were derived from these natural diterpenoids and tested the inducibility of phagocytosis.
天然有機化合物討論会の論文
1991-09-07