Studies on Differentiation-Inducing Activities of Triterpenes
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概要
- 論文の詳細を見る
Differentiation-inducing activity of over 180 extracts of ctude drugs and plants was tested using mouse myeloid leukemia cell line (M1). The methanol extracts of clove (Syzygium aromaticum MERRILL et PERRY, Myrtaceae) showed remarkable induction of differentiation of M1 cells into macrophage-like cells. From the extract, oleanolic acid (1) and crategolic acid (2) were isolated as the active components. We also tested other triterpenes, such as oleananes, ursanes and dammaranes, to investigate the structure-activity relationship. Some triterpene aglycones showed differentiation-inducing activity, but triterpene glycosides showed little activity. Futhermore, the differentiation-inducing activity of these triterpene compounds was tested against human acute promyelocytic leukemia cell line (HL-60).
- 社団法人日本薬学会の論文
- 1992-02-25
著者
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黒柳 正典
静岡県大・薬
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上野 明
School Of Pharmaceutical Sciences University Of Shizuoka
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黒柳 正典
School of Bioresources, Hiroshima Prefectural University
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梅原 薫
School of Pharmaceutical Sciences, University of Shizuoka
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滝 孝雄
Faculty of Medicine, Tokyo Medical and Dental University
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高木 理恵子
School of Pharmaceutical Sciences, University of Shizuoka
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滝 孝雄
School of Medicine, Tokyo Medical and Dental University
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陳 英杰
Department of Phytochemistry, Shenyang College of Pharmacy
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上野 明
School Of Pharmaceutical Science University Of Shizuoka
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滝 孝雄
Faculty Of Medicine Tokyo Medical And Dental University
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黒柳 正典
School Of Bioresources Hiroshima Prefectural University
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陳 英杰
Department Of Phytochemistry Shenyang College Of Pharmacy
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高木 理恵子
School Of Pharmaceutical Sciences University Of Shizuoka
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Umehara K
School Of Pharmaceutical Sciences University Of Shizuoka
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梅原 薫
School Of Pharmaceutical Sciences University Of Shizuoka
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