Establishment and Characterization of Two Cell Lines Derived from Canine Spontaneous Osteosarcoma.

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概要

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• Two new canine osteosarcoma cell lines were established. One (OOS) was established from a 10-year-old female maltese dog with mandibular osteosarcoma and the other (HOS) from a 7-year-old male mongrel dog with scapular osteosarcoma. Histopathological types of OOS and HOS were mixed and fibroblastic cell type, respectively. Transmission electron microscopic features of HOS revealed prominent rough endoplasmic reticulum, suggesting higher malignancy comparing to OOS. Doubling time of OOS and HOS were 45.0 ± 0.5 hr and 42.0 ± 0.1 hr, respectively. Alkaline phosphatase activities of OOS and HOS were quite low. Histological features of tumor tissues produced by transplantation of these cells into nude mice were identical to those of original osteosarcomas.

• 公益社団法人 日本獣医学会の論文

著者

• NISHIMURA Ryohei

  Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The

• MOCHIZUKI Manabu

  Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, Tokyo University of

• SASAKI Nobuo

  Laboratory of Surgery, Veterinary Medical Science, The University of Tokyo

• KADOSAWA Tsuyoshi

  Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069–8501, Japan

• HONG Sung-Hyeok

  Laboratory of Veterinary Surgery, Division of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo

• MATSUNAGA Satoru

  Veterinary Medical Center, Faculty of Agriculture, The University of Tokyo

• NISHIMURA Ryohei

  Laboratory of Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo

• KADOSAWA Tsuyoshi

  Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University

• SASAKI Nobuo

  Laboratories of Veterinary Surgery, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo

• KADOSAWA Tsuyoshi

  Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University

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