Efficacy of Antivascular Photodynamic Therapy Using Benzoporphyrin Derivative Monoacid Ring A (BPD-MA) in 14 Dogs with Oral and Nasal Tumors(Surgery)
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概要
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Antivascular photodynamic therapy (PDT) suppresses tumor growth and prolonged the survival in solid tumor-bearing mice. The purpose of this study was to assess the efficacy of antivascular PDT using BPD-MA for treatment of oral and nasal tumors in 14 dogs. At 15min after initiating intravenous infusion of 0.5mg/kg benzoporphyrin derivative monoacid ring A, tumors were irradiated with laser light at 690nm emitted by a diode laser. The 1-year survival rate of 7 dogs with oral tumors was 71%. The 1-year survival rate of 7 dogs with nasal tumors was 57%. Imaging of each tumor was performed by using angiographic computed tomography before and after each antivascular PDT. Contrast-enhanced tumors were observed before antivascular PDT, but these tumors were not enhanced with contrast medium following antivascular PDT. Antivascular PDT is suggested to be a promising method for dogs with oral and nasal tumors that cannot be effectively treated with current antitumor therapies.
- 社団法人日本獣医学会の論文
- 2009-02-25
著者
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OKUMURA Masahiro
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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KADOSAWA Tsuyoshi
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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FUJINAGA Toru
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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Fujinaga T
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Fujinaga Toru
Hokkaido Univ. Sapporo Jpn
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Fujinaga Toru
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Takagi Satoshi
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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OSAKI Tomohiro
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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HOSHINO Yuki
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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Okumura Masahiro
Hokkaido Univ. Hokkaido Jpn
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Okumura Masahiro
Laboratories Of Veterinary Surgery Graduate School Of Veterinary Medicine Hokkaido University
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Kadosawa Tsuyoshi
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Kadosawa Tsuyoshi
Department Of Small Animal Clinical Sciences School Of Veterinary Medicine Rakuno Gakuen University
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Hoshino Yuki
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Osaki Tomohiro
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Okumura M
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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KADOSAWA Tsuyoshi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069–8501, Japan
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KADOSAWA Tsuyoshi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University
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