Ultrasonography, Biochemical and Hematological Profiles in Liver Disease Caused by Intravenous Administration of Dimethylnitrosamine in Dogs
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概要
- 論文の詳細を見る
The results of liver function tests and ultrasonographical findings were analysed in 7 dogs that were intravenously injected dimethylnitrosamine (DMNA 2 mg/kg body weight) on 2 consecutive days each week for 10 weeks. Typical clinical signs and similar changes in liver enzyme concentrations that develop in dogs with natural cirrhosis were observed in this canine model. Severe anaemia and a significant reduction in the platelet numbers occurred in the dogs that died in the 5th week, while in all the other dogs these parameters decreased slightly. Serum total protein and the albumin/ globulin ratio decreased gradually while the alkaline phosphatase, alanine amino transferase, aspartate amino transferase and gamma glutamyl transpeptidase activities increased significantly (p<0.05) in all dogs after beginning the administration of DMNA. Ultrasound findings of a coarsened and heterogeneous echo pattern with increased echogenicity that are characteristic of canine cirrhosis were noticed at the same time when the changes in liver enzymes became evident. Present results suggest that ultrasonography in conjunction with liver function tests may be useful in the evaluation of experimentally induced liver cirrhosis.
- 北海道大学の論文
- 1997-11-28
著者
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Mwanza Timothy
北海道大学大学院獣医研究科診断治療学講座獣医外科学教室
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Mwanza T
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Mwanza Timothy
北海道大学 大学院
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Mwanza Timothy
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Timothy Mwanza
北海道大学 大学院 診断治療
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MIYAMOTO Toru
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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OKUMURA Masahiro
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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KADOSAWA Tsuyoshi
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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FUJINAGA Toru
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Vet
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Fujinaga T
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Fujinaga Toru
Hokkaido Univ. Sapporo Jpn
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Fujinaga Toru
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Okumura Masahiro
Hokkaido Univ. Hokkaido Jpn
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Okumura Masahiro
Laboratories Of Veterinary Surgery Graduate School Of Veterinary Medicine Hokkaido University
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Kadosawa Tsuyoshi
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Kadosawa Tsuyoshi
Department Of Small Animal Clinical Sciences School Of Veterinary Medicine Rakuno Gakuen University
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Miyamoto Toru
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Okumura M
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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KADOSAWA Tsuyoshi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069–8501, Japan
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KADOSAWA Tsuyoshi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University
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- Ultrasonography, Biochemical and Hematological Profiles in Liver Disease Caused by Intravenous Administration of Dimethylnitrosamine in Dogs
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