Preventive Effect of Hyaluronic Acid on the Suppression of Attachment and Migration Abilities of Bovine Chondrocytes by IL-1.ALPHA. in vitro.
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概要
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Attachment and migration of bovine chondrocytes cultured in vitro were significantly suppressed by the addition of interleukin (IL)-1α at the concentration of 1 ng/ml or more (p<0.05). The application of hyaluronic acid (HA) at the concentration of 10 μg/m l or more significantly recovered the attachment of chondrocytes (p<0.05) and the application of HA at 100 μg/ml concentration recovered the migration of chondrocytes suppressed by IL-1α. These results suggest that the application of HA for inflammatory arthropathies or chondrocyte transplantation might be helpful to preserve the properties of chondrocytes and its extracellular matrix against inflammatory conditions.
- 公益社団法人 日本獣医学会の論文
著者
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Kim Gonhyung
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Fujinaga Toru
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Ishiguro Taketo
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences School Of Veterinary Med
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Okumura Masahiro
Laboratories Of Veterinary Surgery Graduate School Of Veterinary Medicine Hokkaido University
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KADOSAWA Tsuyoshi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069–8501, Japan
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FUJINAGA Toru
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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