Cardiovascular Reflex Mechanisms by Topical Instillation of Capsaicin and Distilled Water into the Larynx in Anesthetized Dogs.
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概要
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Cardiovascular reflex mechanisms by topical laryngeal instillation of capsaicin (CAPS) or distilled water were evaluated in anesthetized chronic tracheostomized dogs. Both CAPS (10 μg/ml) and water instillation into the isolated upper airway caused a significant decrease in heart rate (P<0.05) and a significant increase in blood pressure (P<0.05) from the values before instillation under both spontaneous and controlled ventilation. The bradycardia was significantly reduced by atropine pretreatment (P<0.05) and the hypertension was significantly decreased by phentolamine and propranolol pretreatments (P<0.01). A higher concentration of CAPS (100 μg/m l) instillation considerably reduced the response to subsequent CAPS (100 μg/ml) instillation, whereas the response to water was sustained, indicating the desensitization of laryngeal CAPS-sensitive endings. All the reflex responses to CAPS and water were eliminated by topical anesthesia with lidocaine. It was concluded that the laryngeal cardiovascular reflex responses were mediated by the afferents such as the laryngeal CAPS-sensitive presumably C-fiber endings or water-responsive receptors and by both the parasympathetic and sympathetic nervous systems as efferents.
- 公益社団法人 日本獣医学会の論文
著者
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NISHIMURA Ryohei
Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The
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Tsubone Hirokazu
Laboratory Of Veterinary Pathophysiology Faculty Of Agriculture Tokyo University
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SASAKI Nobuo
Laboratory of Surgery, Veterinary Medical Science, The University of Tokyo
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MUTOH Tatsushi
Laboratories of Veterinary Surgery, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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NISHIMURA Ryohei
Laboratory of Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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TSUBONE Hirokazu
Laboratories of Comparative Pathophysiology, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SASAKI Nobuo
Laboratories of Veterinary Surgery, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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