Threshold Changes in Auditory Brainstem Response (ABR) Due to the Administration of Kanamycin in Dogs

スポンサーリンク

概要

• 論文の詳細を見る

• Auditory brainstem response (ABR) is a useful method in evaluating auditory function in human. To investigate the ABR threshold is more effective than to pursue the trends in each component of ABR. In this study, tone burst sound stimuli were employed and the ABR threshold shift caused by kanamycin administration was investigated in dogs. In a series of monitoring of ABR against short-period auditory lesions, changes in the ABR waveform after intravenous administration of kanamycin were detected. These changes returned gradually and were reversible. The changes in ABR against long-period auditory function disorder were perceived by an increase in the ABR threshold. The ABR threshold shift occurred earlier in the high frequency sounds than in the lower frequency sounds. This is why amino glycoside antibiotics damage the cochlear hair cells in the basal layer and lead to the loss of hearing selectively for high frequency tones. These findings suggest that tracing of the ABR threshold by tone bursts could provide information that has a specificity for frequency in hearing tests and is a useful method in clinical veterinary medicine or/and toxicological tests.

• 社団法人　日本実験動物学会の論文
• 1996-10-01

著者

• Tsubone Hirokazu

  Laboratory Of Veterinary Pathophysiology Faculty Of Agriculture Tokyo University

• Ohnishi Takafumi

  Laboratory Of Veterinary Internal Medicine Faculty Of Agriculture Yamaguchi University

• Sugano Shigeru

  Laboratory Of Veterinary Pathophysiology Faculty Of Agriculture Tokyo University

• UZUKA Yuji

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• FURUTA Tomohiro

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• YAMAOKA Mayumi

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• Uzuka Yuji

  Laboratory Of Veterinary Internal Medicine Faculty Of Agriculture Yamaguchi University

• Yamaoka Mayumi

  Laboratory Of Veterinary Internal Medicine Faculty Of Agriculture Yamaguchi University

• Furuta Tomohiro

  Laboratory Of Veterinary Internal Medicine Faculty Of Agriculture Yamaguchi University

• TSUBONE Hirokazu

  Laboratories of Comparative Pathophysiology, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo

関連論文

• Threshold Changes in Auditory Brainstem Response (ABR) Due to the Administration of Kanamycin in Dogs
• Effect of Simultaneous Bilateral Tibial Nerve Stimulation on Somatosensory Evoked Potentials (SEP) in Dogs
• Cardiovascular Reflex Mechanisms by Topical Instillation of Capsaicin and Distilled Water into the Larynx in Anesthetized Dogs.
• Comparison of the Upper Gastrointestinal Effects of Etodolac and Aspirin in Healthy Dogs.

スポンサーリンク