Comparison of Macrophage Scavenger Receptor-A Knockout Mice with Wild Type Ones in the Immune Response against Repeated Infestation with Haemaphysalis longicornis

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概要

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• Using macrophage scavenger receptor-A knockout (SRKO) mice, we examined the role of macrophage class A scavenger receptors (MRS-A) on the immune response and acquisition of host resistance against repeated infestation with Haemaphysalis longicornis. Except for one batch of nymphs that infested one of the SRKO (SR-/-) mice and showed no appreciable reduction in body weight, all the other groups of nymphs manifested significant decrease in body weight. Both SR-/- and wild type (SR+/+) mice showed a sustained increase in anti-tick antibody titers, but SR+/+ mice showed significantly higher titers. The IFN-γ assayed in SR-/- mouse immune sera was substantially less compared with that in SR+/+ mice. Immune sera from SR-/- and SR+/+ mice recognized the 51 and 44 kDa, and 44 kDa proteins, respectively, of the salivary gland antigen. The difference in the level of anti-tick resistance manifested by both groups of mice may be influenced by less efficient trapping and processing of tick antigens by macrophages in mice lacking for the macrophage scavenger receptors, and consequently affected the cascade of Th1 and Th2 responses. We have thus obtained valuable data that strongly infer the role of MSR-A in enhancing host defense against repeated infestation with H. longicornis.

著者

• SUZUKI Hiroshi

  National Research Center for Profozoan Diseases, Obihiro University of Agriculture and Veterinary Me

• KAMIO Tsugihiko

  National Institute of Animal Health

• Toyoda Yutaka

  National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med

• Tsuji Naotoshi

  National Institute Of Animal Health

• Igarashi Ikuo

  National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med

• Fujisaki Kozo

  National Institute Of Animal Health

• Nagasawa Hideyuki

  National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med

• TOYODA Yutaka

  National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

• NAGASAWA Hideyuki

  National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

• KABAMOTO Satoshi

  National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

• BHAGAT Negi

  National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

• YOU Myungjo

  National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

• CLAVERIA Florencia

  National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

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