Leucine Aminopeptidase in the Ixodid Tick Haemaphysalis longicornis: Endogenous Expression Profiles in Midgut

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概要

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• We previously identified a cDNA from the ixodid tick Haemaphysalis longicornis that encodes leucine aminopeptidase, HlLAP. Functionally, recombinant HlLAP effectively hydrolyzed synthetic amino acid derivatives. Here, we investigated the temporal expression profiles of midgut HlLAP in adult H. longicornis parthenogenetic ticks from the starting of blood feeding until just before the onset of oviposition. Midgut HlLAP transcript expression level was higher during post-engorgement period than that during feeding period. Endogenous HlLAP in the midgut was also observed with higher expression level during post-engorgement period. Histological localization of HlLAP was in the cytosol of midgut epithelial cells, notably the newly differentiated basophilic cells at post-engorgement. Our data suggested that HlLAP was dominantly localized in basophilic cells, where it may play regulatory roles in protein biosynthesis and degradation.

• 社団法人　日本獣医学会の論文

著者

• MIYOSHI Takeharu

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Foo

• HATTA Takeshi

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Foo

• ALIM M.

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agriculture and Food

• Tsuji Naotoshi

  Laboratory Of Parasitic Diseases National Institute Of Animal Health National Agriculture Research O

• Fujisaki Kozo

  National Institute Of Animal Health

• Hatta Takeshi

  National Institute Of Animal Health National Agriculture And Food Research Organization

• Islam M.

  Laboratory Of Biochemistry And ** Laboratory Of Protein Chemistry & Engineering Faculty Of Agric

• Tsuji Naotoshi

  National Institute Of Animal Health National Agriculture And Food Research Organization

• Miyoshi Takeharu

  National Institute Of Animal Health National Agriculture And Food Research Organization

• TSUJI Naotoshi

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization

• ALIM M.

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization

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