Comparison of the Growth Inhibitory Effects of Canine IFN-.ALPHA., -.BETA. AND -.GAMMA. on Canine Cells Infected with Neospora caninum Tachyzoites.
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概要
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The growth inhibitory effects of recombinant canine interferon alpha (IFN-α), beta (IFN-β) and gamma (IFN-γ) were examined on Madin-Darby canine kidney cells infected with Neospora caninum tachyzoites. The parasite growth was inhibited by all IFNs in a dose-dependent manner. IFN-γ inhibited the parasite growth with greater efficacy than IFN-α or IFN-β. Moreover, the effect of IFNs on N. caninum growth associated with the suppression of the host cell viability. The present study indicates IFN-a and -β, besides IFN-γ, play a crucial role for N. caninum growth in host cells.
- 公益社団法人 日本獣医学会の論文
著者
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Otsuka Haruki
Department Of Global Agricultural Sciences Granduate School Of Agricultural And Life Science The Uni
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Fujisaki Kozo
National Institute Of Animal Health
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Nagasawa Hideyuki
National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med
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IWATA Akira
Nippon Institute for Biological Science, 9–2221–1 Shinmachi, Ome, Tokyo 198–0024, Japan
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NISHIKAWA Yoshifumi
National Research Center for Protozoan Deseases, Obihiro University of Agriculture and Veterinary Medicine
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NAGASAWA Hideyuki
National Research Center for Protozoan Diseases, Obihiro University
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MIKAMI Takeshi
National Research Center for Protozoan Diseases, Obihiro University
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OTSUKA Haruki
Department of Global Agricultural Science, The University of Tokyo
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