Prevalence and Dynamics of Antibodies against NcSAG1 and NcGRA7 Antigens of Neospora caninum in Cattle during the Gestation Period

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概要

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• Bovine abortion caused by the Apicomplexan parasite Neospora caninum is a major economic problem in the livestock industry worldwide. Our study measured the prevalence and temporal changes in levels of antibodies specific for two N. caninum derived antigens, NcSAG1 and NcGRA7 to determine an appropriate strategy for serodiagnosis. Using the Enzyme-Linked Immuno Sorbent Assay (ELISA), blood samples showed that 71 cows out of 129 were positive for anti-NcSAG1 antibodies and only nine cows were positive for anti-NcGRA7 antibodies. By longitudinal sampling, it was revealed that positive and negative antibody conversion occurred frequently for anti-NcGRA7, but that anti-NcSAG1 antibodies persisted long-term. These results indicate the usefulness of measuring anti-NcSAG1 antibody levels for the detection of chronically infected cows. Twelve cows showed positive sero-conversion during pregnancy, nine of which showed sero-positivity for anti-NcGRA7 antibody at the sixth and/or seventh month of pregnancy; serum samples were not obtained from the remaining three cows during this period. Therefore, the optimal time for detection of anti-NcGRA7 antibodies appears to be between the fifth and eighth month of pregnancy.

著者

• Takashima Yasuhiro

  Department Of Information And Media The University Of Kitakyushu

• KITOH Katsuya

  Department of Veterinary Parasitological Diseases, Gifu University

• Nishikawa Yoshifumi

  National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med

• BATANOVA Tatiana

  Department of Veterinary Parasitological Diseases, Gifu University

• Hattori Naoki

  Department Of Healthy Food Kanematsu Wellness Corporation

• TAKASHIMA Yasuhiro

  Department of Veterinary Parasitology, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• TAKASU Masaki

  Department of Veterinary Clinical Theriogenology, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• YANAGIMOTO Isao

  Department of Veterinary Parasitology, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• KITOH Katsuya

  Department of Veterinary Parasitology, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• KITOH Katsuya

  Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University

• BATANOVA Tatiana

  Department of Veterinary Parasitology, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• NISHIKAWA Yoshifumi

  National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080–8555, Japan

• NISHIKAWA Yoshifumi

  National Research Center for Protozoan Deseases, Obihiro University of Agriculture and Veterinary Medicine

• TAKASU Masaki

  Department of Clinical Veterinary Medicine, United Graduate School of Veterinary Sciences, Gifu University

• HATTORI Naoki

  Department of Veterinary Parasitology, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

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