Pain-related Differential Expression of NGF, GDNF, IL-6, and Their Receptors in Human Vasculitic Neuropathies
スポンサーリンク
概要
- 論文の詳細を見る
Objective Pain-related differential expressions of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and interleukin-6 (IL-6), and their receptors were investigated in human vasculitic neuropathies. Materials and Methods The mRNA levels of painrelated neurotrophic factors, NGF, GDNF and IL-6, were examined in the sural nerves of 22 painful and non-painful patients with acute necrotizing vasculitic neuropathies, together with their concomitant soluble receptors (p75, GFRα-1 and IL-6Rα). Results The mRNAs for these factors and receptors in the lesioned nerves were up-regulated to a variable extent in both groups. NGF mRNA expression was more closely correlated with that of p75 in painful neuropathy with relatively preserved large fiber density, compared with non-painful neuropathy, though the NGF mRNA level in painful neuropathy was lower than that in non-painful neuropathy. GDNF was closely associated with GFRα-1 in mRNA levels regardless of the pain state, but IL-6 was not associated with IL-6Rα. Conclusion The differential expression of neurotrophic factors and their cognate soluble receptors in human vasculitic neuropathy suggests that NGF, which was effectively transferred to sensory axons with p75, may induce pain.(Internal Medicine 42: 1100-1103, 2003)
- 社団法人 日本内科学会の論文
- 2003-11-01
著者
-
Hattori Naoki
Department Of Neurology Nagoya University Graduate School Of Medicine
-
Ito Yasuhiro
Department Of Surgery Ii Osaka University Medical School
-
Sobue Gen
Department Of Neurology Nagoya University Graduate School Of Medicine
-
Yamamoto Masahiko
Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ
-
MITSUMA Norimasa
Department of Neurology, Nagoya University Graduate School of Medicine
-
Hattori Naoki
Department Of Healthy Food Kanematsu Wellness Corporation
-
Yamamoto Masahiko
Department Of Neurology Nagoya University Graduate School Of Medicine
-
Ito Yasuhiro
Department Of Dermatology Asahikawa Medical College
-
Ito Yasuhiro
Department Of Cell Differentiation The Sakaguchi Laboratory School Of Medicine Keio University
-
Ito Yasuhiro
Department Of Neurology Nagoya University Graduate School Of Medicine
-
Mitsuma Norimasa
Department Of Neurology Nagoya University Graduate School Of Medicine
-
SOBUE Gen
Department of Internal Medicine, Aichi Medical University School of Medicine
関連論文
- Crystal Structure and Magnetic Properties of Cr-Doped AlN Films with Various Cr Concentrations
- Formation of L1_0-type Ordered FePd Phase in Multilayers Composed of Fe and Pd
- Surface Structure of Self-Organized Sapphire (0001) Substrates with Various Inclined Angles
- Morphology of Fe Film Grown on Self-Organized SrTiO_3(001) Substrates with Inclined Angles
- Magnetic States and Magnetization Processes of Ni-Fe/Hf Annular Dots as Candidates of Non-Volatile Memory Cells
- Magnetic and Electric Properties in C/Mn/C/Si Multilayers
- Immunohistochemical Study of Cell Cycle Modulators in G_1-S Transition in Clinical Breast Cancer Tissue
- Studies of self-Organized Steps and Terraces in inclined SrTiO_3 (001) Substrate by Atomic Force Microscopy
- Clinicopathologic characteristics of five autopsied cases of dura mater-associated Creutzfeldt-Jakob disease
- A Case of Basal Cell Carcinoma of the Nipple and Areola with Intraductal Spread
- Investigation of visual disorders of subacute myelo-optico-neuropathy (SMON) patients 32 years after onset : Questionnaire-based survey and ophthalmological examination
- Molecular-Beam Epitaxial Growth of(001)Cr/Al/Cr/Al Quadrilayer Superlattice Containing One-Monolayer-Thick Cr Layers
- Stranski-Krastanov Growth of Al on Ag Layers during Molecular Beam Epitaxy of(111) Al/Ag Superlattices
- Molecular-Beam Epitaxial Growth of Short-Period(001)Al/Ag/Cr Superlattices with Intermediary Ag Layers
- Solid-State Amorphization in Al/Pd Multilayer during Near-Room-Temperature Molecular-Beam Deposition
- Molecular Beam Epitaxial Growth and Structures of Al/Ag Superlattices
- Structure and Magnetic Properties of [Ag/Ni/Au] and [Au/Ni/Ag] Superlattices
- An Infant Case of Macroprolactinemia with Transient Idiopathic Central Precocious Puberty
- Prognosis of Patients with Papillary Thyroid Carcinoma Having Clinically Apparent Metastasis to the Lateral Compartment
- Preoperative Administration of Excess Iodide Increases Thyroid Volume of Patients with Graves' Disease
- Clinical Significance of Extrathyroid Extension to the Parathyroid Gland of Papillary Thyroid Carcinoma
- Prognosis of Patients with Papillary Carcinoma Showing Anaplastic Transformation in Regional Lymph Nodes that Were Curatively Resected
- Subclassification of non-solid-type papillary thyroid carcinoma identification of high-risk group in common type
- Distant and Lymph Node Metastases of Thyroid Nodules with No Pathological Evidence of Malignancy : A Limitation of Pathological Examination
- Prevalence and Prognosis of Familial Follicular Thyroid Carcinoma
- Field-Ion Images of Ordered Ni_3Mo Alloy and Their Computer Simulation
- Field-Evaporation End Form of Ordered Ni_4Mo Alloy
- A Method of Determining the Types of Ordered Domains of β-Ni_4Mo in Field-Ion Images
- Field-Ion Microscope Study of Early Stages of Ordering in Ni_4Mo Alloy
- Autopsy case of lymphoplasmacytic lymphoma with a large submucosal tumor in the stomach
- Relationship between pollen counts of Cryptomeria japonica and Cupressaceae and the severity of allergic symptoms
- Zep: A Novel Zinc Finger Protein Containing a Large Proline-Rich Domain
- 4 Angiopoietin-related growth factor (AGF) promotes angiogenesis(Young Investigator's Award Finalists Lectures (YIA))(Special Program)
- Malignant mesothelioma of the pericardium : Case reports and immunohistochemical studies including Ki-67 expression
- Scanning Tunneling Microscopy and Atomic Force Microscopy Study on Interface between Molecular-Beam-Grown Pt Film and Si (111) Substrate
- Scanning Tunneling Microscope and Atomic Force Microscope Observation of Topography of Molecular-Bearm-Epitaxy-Grown Pt Films on Cu Buffer Layer and Si(111)-(7×7) Substrate
- Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease
- Sensory Conduction Study of Cisplatin Neuropathy: Preservation of Small Myelinated Fibers
- Spin-Crossover Behaviors of Iron(III) Compounds with Strong Intermolecular Interactions
- Interlayer Exchange Coupling of Fe/Y Multilayers
- Change of Interlayer Exchange Coupling in Fe/Y Multilayers by Hydrogenation
- Direct Retroperitoneal Open Drainage via a Long Posterior Oblique Incision for Infected Necrotizing Pancreatitis : Report of Three Cases
- Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA
- EFFECT OF FLUORIDE ON PHYSIOLOGICAL ION MOBILIZATIONS IN RATS
- Mossbauer Study on the Electron Transfer Rate Depending on the Intermolecular Interaction in Iron(II,III) Mixed-Valence Complex
- Computer-Simulated Field-Ion Images of Ni_4Mo Alloy for Statistically Homogeneous Ordering
- Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement
- Long-Term Clinical Course of Two Cases of Lymphocytic Adenohypophysitis
- Immunoglobulin G Can Cross-React With Glucagon Antisera and Cause a Spuriously High Plasma Immunoreactive Glucagon Level
- Restoration of Leydig cells after repeated administration of ethane dimethanesulfonate in adult rats
- Encapsulated Anaplastic Thyroid Carcinoma Without Invasive Phenotype with Favorable Prognosis : Report of a Case
- GABA_C-Receptor Stimulation Activates cAMP-Dependent Protein Kinase via A-Kinase Anchoring Protein 220
- Clinicopathological Findings and p53 Expression of Thyroid Cancer in Children
- Expression of p57/Kip2 Protein in Pancreatic Adenocarcinoma
- Expression of cdc25A and cdc25B Phosphatase in Breast Carcinoma
- Multiple Cerebellar Infarcts : Clinical and Pathophysiologic Features
- Rapidly Progressive Fatal Respiratory Failure (Ondine's Curse) in the Lateral Medullary Syndrome
- Inflammatory pathological changes in a 2-year-old boy with Charcot-Marie-Tooth disease
- The Protective Effect of a Parsistent Trigeminal Artery on Brain Stem Infarctions: A Follow-up Case Report
- Minimal Extrathyroid Extension Does Not Affect the Relapse-Free Survival of Patients with Papillary Thyroid Carcinoma Measuring 4cm or Less over the Age of 45 Years
- Prognosis After Reoperation for Local Recurrence of Papillary Thyroid Carcinoma
- Macrofollicular Variant of Papillary Thyroid Carcinoma : Its Clinicopathological Features and Long-Term Prognosis
- Classification of follicular cell tumors of the thyroid gland : Analysis involving Japanese patients from one institute
- Prognostic Factors and Therapeutic Strategies for Differentiated Carcinomas of the Thyroid
- Widespread spinal cord involvement in progressive supranuclear palsy
- Hypercalcemia associated with squamous cell carcinoma arising in pyoderma chronica
- Synthesis of lipid derivatives of pyrrole polyamide and their biological activity
- Malignant melanoma of the breast : N-isopropyl-p-^I-iodoamphetamine single photon emission computed tomography (^I-IMP SPECT) is useful for the detection of metastasis
- X-linked Recessive Bulbospinal Neuronopathy (SBMA)
- Clinical and Pathophysiological Features of Amaurosis Fugax in Japanese Stroke Patients
- Crow-Fukase syndrome
- Pain-related Differential Expression of NGF, GDNF, IL-6, and Their Receptors in Human Vasculitic Neuropathies
- Pyramidal tract degeneration in sporadic Creutzfeldt-Jakob disease
- Mechanism of Thermal Faceting of Ni_4Mo Alloy Emitters
- Field-Ion Microscope Observation of Thermal Faceting in Ni_4Mo Emitter
- Field-Ion Microscope Studies of Ni_4W Type Ordering in the Near-Surface of Ni-16.6 at%W Alloy
- Field-Ion Microscope Study of Ordering in the Near-Surface of Ni_4Mo Alloy
- Field-Ion Microscope Observation of Deformation Twin Induced by Field Stress in Ordered Ni_4Mo Alloy
- Effect of Intake of Immune Milk Product on the Fecal Microflora in Healthy Female Volunteers
- Cellulitis due to gas-producing organism with niveau formation
- An autopsied case of panencephalopathic-type Creutzfeldt-Jakob disease with mutation in the prion protein gene at codon 232 and type 1 prion protein
- Two cases of mycosis fungoides treated by reduced-intensity cord blood transplantation
- Synthesis and Characterization of trans[CoCl_2(232N_4x)]^+(232N_4x=1,4,8,11Tetraazacyclopentadecane, -cyclohexadecane, -cycloheptadecane, -cyclooctadecane, -cyclononadecane, -cycloicosane, -cyclohenicosane, and -cyclotricosane)
- Argyrophilic nucleolar organizer regions in colorectal malignancy : Application of typing by their density
- Pathogenesis-targeting therapeutics for spinal and bulbar muscular atrophy (SBMA)
- Delayed cardiac rupture occurring two months after blunt chest trauma
- Local Probing of Vortex Core Movement in a Ni–Fe Disk Using Magnetic Field Sweeping-Magnetic Force Microscopy
- A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt-Jakob disease
- Annular dots as candidates of non-volatile memory cells
- Magnetization Reversal with In-Plane Magnetic Field in Asymmetric Ring Dots
- Observation of Magnetization Reversal Process in Ni–Fe Nanowire Using Magnetic Field Sweeping-Magnetic Force Microscopy
- Magnetic Properties in Mn/Si–O/Si(100)-substrate Systems and Mn/Si–O/Si Trilayers
- Structural and Magnetic Properties of Dy/Cr Multilayers and Bilayers Grown by Molecular-Beam Deposition
- Growth Behavior of Dy/Cr Multilayers during Molecular-Beam Epitaxy and Their Structures
- Molecular-Beam Epitaxial Growth and Structures of Dy on (100) and (211)Cr Thin Films
- Inheritance of Crystal Structure in Cu/Co and Co/Cu Bilayers Grown on MgO(100) Substrate
- Trapping of Magnetic Domain Wall in Nickel Constriction
- Magnetic States and Magnetization Process in Ni–Fe Sub-micron Cup-Shaped Dots
- Investigation of Self-Organized Steps and Terraces in SrTiO3 (001) Substrate Inclined in [110] Direction by Scanning Tunneling Microscopy
- Magnetic Property and Morphology of Fe Film Grown on Self-Organized SrTiO3 (001) Substrate with Inclined Angle