Effects of Growth Hormone on the Differentiation of Mouse B-Lymphoid Precursors
スポンサーリンク
概要
- 論文の詳細を見る
Growth hormone (GH) has been known to enhance immune responses directly or through insulin-like growth factor-I (IGF-I). The present study aimed to clarify the roles of GH in the differentiation of B-lineage precursors. In short-term bone marrow cultures, which contained stem cells and early B-lineage cells, GH (10 μg/L) treatment for one day decreased the percentages of stem cells (0.5-fold) and increased those of B-lineage cells (1.4-fold). Furthermore, GH changed the expressions of transcription factors for B cell progenitors differentiation such as paired box gene-5 (Pax-5), immunoglobulin-associated-α (Ig-α)/CD79a, Ig-β/CD79b, and IGF-I. Thus, a physiological concentration of GH stimulated the differentiation of B-lymphoid precursors from bone marrow stem cells. Since mRNAs of both GH and GH receptor were present in stem cells and B-cell precursors in bone marrow, GH may modulate B-lymphoid precursors development in an autocrine or paracrine manner in bone marrows.
- 社団法人 日本薬理学会の論文
- 2005-03-20
著者
-
Inagaki Chiyoko
Department of Pharmacology, Kansai Medical University, Japan
-
HATTORI NAOKI
Department of Pharmacology, Kansai Medical University
-
Inagaki Chiyoko
Department Of Biology Kyoto College Of Pharmacy
-
SUMITA Kiminobu
Department of Pharmacology, Kansai Medical University
-
Sumita Kiminobu
Department Of Pharmacology Kansai Medical University
-
Hattori Naoki
Department Of Healthy Food Kanematsu Wellness Corporation
-
INAGAKI Chiyoko
Departmctit of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1–Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes
- An Infant Case of Macroprolactinemia with Transient Idiopathic Central Precocious Puberty
- Adrenergic Receptor-Mediated Cl^- Transport in Rabbit Corneal Endothelial Cells
- Long-Term Clinical Course of Two Cases of Lymphocytic Adenohypophysitis
- Immunoglobulin G Can Cross-React With Glucagon Antisera and Cause a Spuriously High Plasma Immunoreactive Glucagon Level
- GABA_C-Receptor Stimulation Activates cAMP-Dependent Protein Kinase via A-Kinase Anchoring Protein 220
- Molecular Mechanisms for α_2-Adrenoceptor-Mediated Regulation of Synoviocyte Populations
- Phorbol 12-Myristate 13-Acetate(PMA)-Induced Oxyradical Production in Rheumatoid Cells
- Natriuretic Peptide Receptors, NPR-A and NPR-B, in CulturedRabbit Retinal Pigment Epithelium Cells
- Inflammatory pathological changes in a 2-year-old boy with Charcot-Marie-Tooth disease
- Effects of Growth Hormone on the Differentiation of Mouse B-Lymphoid Precursors
- Macroprolactinemia : a New Cause of Hyperprolactinemiae
- Immunohistochemical Demonstration of CI^- Pump in Type A Intercalated Cells of Rat Kidney
- POSSIBLE MECHANISMS OF THE TRIPHASIC EFFECTS OF NEUROTENSIN ON THE RAT BLOOD PRESSURE
- UPTAKE OF 14C-LABELLED 5-HYDROXYTRYPTOPHAN AND 5-HYDROXYTRYPTAMINE BY SEPARATED RAT RENAL TUBULES
- INHIBITORY EFFECT OF (+)THREO-3, 4-DIHYDROXY-PHENYLSERINE (DOPS) ON DECARBOXYLATION OF (-)THREO-DOPS
- INHIBITORY EFFECTS OF D-ISOMERS OF AROMATIC AMINO ACIDS ON THE DECARBOXYLATION OF L-5-HYDROXYTRYPTOPHAN
- NEONATAL AND SENESCENT CHANGES IN L-AROMATIC AMINO ACID DECARBOXYLASE AND MONOAMINE OXIDASE ACTIVITIES IN KIDNEY, LIVER, BRAIN AND HEART OF THE RAT
- EFFECTS OF DIAZEPAM, NITRAZEPAM AND BROTIZOLAM ON DOPAMINE TURNOVER IN THE OLFACTORY TUBERCLE, NUCLEUS ACCUMBENS AND CAUDATE NUCLEUS OF RATS
- Paradoxical Brain Embolism Induced by Mycoplasma pneumoniae Infection with Deep Venous Thrombus
- Pain-related Differential Expression of NGF, GDNF, IL-6, and Their Receptors in Human Vasculitic Neuropathies
- Effect of Intake of Immune Milk Product on the Fecal Microflora in Healthy Female Volunteers
- RAPID PURIFICATION OF MONOCLONAL ANTIBODY IN ASCITES BY HIGH PERFORMANCE ION EXCHANGE COLUMN CHROMATOGRAPHY FOR DIMINISHING NON-SPECIFIC STAINING
- Na, K-, Mg- AND HCO3-ADENOSINE TRIPHOSPHATASES IN THE RABBIT BRAIN CHOROID PLEXUS
- ENZYMATIC DECARBOXYLATION OF L-THREO-3, 4-DIHYDROXYPHENYLSERINE IN RAT HEART
- Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes
- COMPARISON BETWEEN FLUORIMETRIC AND RADIOCHEMICAL ASSAYS OF IONTOPHORETICALLY RELEASED NORADRENALINE FROM A SEVEN-BARRELED MICROPIPETTE
- EFFECT OF ALDOSTERONE ON RENAL Na, K-ACTIVATED ADENOSINE-TRIPHOSPHATASE ACTIVITY IN NON-ADRENALECTOMIZED RATS
- Sensitization to heat by amiloride analogues in Chinese hamster cells.
- Prevalence and Dynamics of Antibodies against NcSAG1 and NcGRA7 Antigens of Neospora caninum in Cattle during the Gestation Period
- GABAC-Receptor Stimulation Activates cAMP-Dependent Protein Kinase via A-Kinase Anchoring Protein 220
- Purification and Characterization of Neurotrophic Factor for Retinal Cholinergic Neurons Derived from Cultured Hippocampal Neurons.
- Characteristics of ethacrynic acid highly sensitive Mg2+-ATPase in microsomal fractions of the rat brain : Functional molecular size, inhibition by SITS and stimulation by Cl-.
- Solubilization and separation of ethacrynic acid(EA) highly sensitive and EA less sensitive Mg2+-ATPases in the rat brain.
- Ethacrynic Acid-Sensitive and ATP-Dependent Cl- Transport in the Rat Kidney.