Sensitization to heat by amiloride analogues in Chinese hamster cells.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of five amiloride analogues on thermal cell killing were examined using Chinese hamster V-79 cells. When cells were exposed to 42°C hyperthermia in the presence of 0.2 mM amiloride or its analogue, cell survival decreased with increasing exposure time, as compared with that for exposure to 42°C alone. The degree of the thermosensitizing effect varied among the test compounds, and three analogues were found to be more potent than amiloride. The results suggest that some of the amiloride analogues may be useful as hyperthermic sensitizers in the clinical treatment of cancer.
著者
-
Hirata Mitsuru
Department Of Applied Chemistry Tokyo University Of Agriculture And Technology
-
INAGAKI Chiyoko
Departmctit of Pharmacology, Faculty of Medicine, Kyoto University
-
MIYAKOSHI Junji
Radioisotope Laboratory, Faculty of Medicine, Kyoto University
-
ODA Wasako
Department of Biology, Kyoto Pharmaceutical University
-
CRAGOE Jr.
The Merck, Sharp and Dohme Research Laboratories
-
HIRATA Mitsuru
Department of Biology, Kyoto Pharmaceutical University
関連論文
- Adrenergic Receptor-Mediated Cl^- Transport in Rabbit Corneal Endothelial Cells
- GABA_C-Receptor Stimulation Activates cAMP-Dependent Protein Kinase via A-Kinase Anchoring Protein 220
- Molecular Mechanisms for α_2-Adrenoceptor-Mediated Regulation of Synoviocyte Populations
- Phorbol 12-Myristate 13-Acetate(PMA)-Induced Oxyradical Production in Rheumatoid Cells
- Natriuretic Peptide Receptors, NPR-A and NPR-B, in CulturedRabbit Retinal Pigment Epithelium Cells
- Effects of Growth Hormone on the Differentiation of Mouse B-Lymphoid Precursors
- Immunohistochemical Demonstration of CI^- Pump in Type A Intercalated Cells of Rat Kidney
- POSSIBLE MECHANISMS OF THE TRIPHASIC EFFECTS OF NEUROTENSIN ON THE RAT BLOOD PRESSURE
- UPTAKE OF 14C-LABELLED 5-HYDROXYTRYPTOPHAN AND 5-HYDROXYTRYPTAMINE BY SEPARATED RAT RENAL TUBULES
- INHIBITORY EFFECTS OF D-ISOMERS OF AROMATIC AMINO ACIDS ON THE DECARBOXYLATION OF L-5-HYDROXYTRYPTOPHAN
- NEONATAL AND SENESCENT CHANGES IN L-AROMATIC AMINO ACID DECARBOXYLASE AND MONOAMINE OXIDASE ACTIVITIES IN KIDNEY, LIVER, BRAIN AND HEART OF THE RAT
- EFFECTS OF DIAZEPAM, NITRAZEPAM AND BROTIZOLAM ON DOPAMINE TURNOVER IN THE OLFACTORY TUBERCLE, NUCLEUS ACCUMBENS AND CAUDATE NUCLEUS OF RATS
- Associative Exchange of a Guanosine Ligand on Triarylphosphine-Gold(I) Complexes
- RAPID PURIFICATION OF MONOCLONAL ANTIBODY IN ASCITES BY HIGH PERFORMANCE ION EXCHANGE COLUMN CHROMATOGRAPHY FOR DIMINISHING NON-SPECIFIC STAINING
- Na, K-, Mg- AND HCO3-ADENOSINE TRIPHOSPHATASES IN THE RABBIT BRAIN CHOROID PLEXUS
- ENZYMATIC DECARBOXYLATION OF L-THREO-3, 4-DIHYDROXYPHENYLSERINE IN RAT HEART
- Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes
- COMPARISON BETWEEN FLUORIMETRIC AND RADIOCHEMICAL ASSAYS OF IONTOPHORETICALLY RELEASED NORADRENALINE FROM A SEVEN-BARRELED MICROPIPETTE
- EFFECT OF ALDOSTERONE ON RENAL Na, K-ACTIVATED ADENOSINE-TRIPHOSPHATASE ACTIVITY IN NON-ADRENALECTOMIZED RATS
- Sensitization to heat by amiloride analogues in Chinese hamster cells.
- GABAC-Receptor Stimulation Activates cAMP-Dependent Protein Kinase via A-Kinase Anchoring Protein 220
- Purification and Characterization of Neurotrophic Factor for Retinal Cholinergic Neurons Derived from Cultured Hippocampal Neurons.
- Characteristics of ethacrynic acid highly sensitive Mg2+-ATPase in microsomal fractions of the rat brain : Functional molecular size, inhibition by SITS and stimulation by Cl-.
- Solubilization and separation of ethacrynic acid(EA) highly sensitive and EA less sensitive Mg2+-ATPases in the rat brain.
- Ethacrynic Acid-Sensitive and ATP-Dependent Cl- Transport in the Rat Kidney.