Ethacrynic Acid-Sensitive and ATP-Dependent Cl- Transport in the Rat Kidney.
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概要
- 論文の詳細を見る
Ouabain- and furosemide-insensitive and ATP-dependent Cl<SUP>-</SUP> uptake was demonstrated in rat renal membrane vesicles. Such a Cl<SUP>-</SUP> uptake activity was prominent in cortical plasma membrane fractions with high activities of Cl<SUP>-</SUP>-ATPase and Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase. The membrane vesicles accumulated Cl<SUP>-</SUP> in an osmotically reactive manner with the following sequence of nucleotide specificity: ATP > ITP > UTP > GTP > CTP., β, γ-Methylene ATP, ADP and AMP had no effect. ATP-dependent Cl<SUP>-</SUP> uptake was markedly inhibited by a Cl<SUP>-</SUP>-ATPase inhibitor, ethacrynic acid (0.3 mM), but not affected by an H<SUP>+</SUP>-ATPase inhibitor, N, N'-dicyclohexylcarbodiimide (0.1 mM). These findings suggest that an ethacrynic acid-sensitive and ATP-driven Cl<SUP>-</SUP> pump is present in the rat renal cortex.
- 公益社団法人 日本薬理学会の論文
著者
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INAGAKI Chiyoko
Departmctit of Pharmacology, Faculty of Medicine, Kyoto University
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Kunugi Yukiko
Department of Biology, Kyoto Pharmaceutical University
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Hashimoto Yoshikatsu
Department of Biology, Kyoto Pharmaceutical University
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Taniguchi Takashi
Department of Biology, Kyoto Pharmaceutical University
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Hiraoka Yasuko
Department of Biology, Kyoto Pharmaceutical University
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