Developmental Stage- and Organ-Specific Expression Profiles of Asparaginyl Endopeptidases/Legumains in the Ixodid Tick Haemaphysalis longicornis(Parasitology)

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概要

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• We previously identified two cDNAs from the midgut of adult Haemaphysalis longicornis that encode asparaginyl endopeptidases/legumains, HlLgm and HlLgm2. Functionally, both recombinant HlLgm and HlLgm2 efficiently digested blood proteins, haemoglobin and bovine serum albumin. Here, we investigated the expression profiles of legumain genes in the developmental stages in the life cycle of H. longicornis and in different tissues of adult ticks. Both HlLgm and HlLgm2 were well expressed in larvae, nymphs and adults. Legumain transcripts were expressed specifically in the midgut and were localized in some digestive vacuoles of gut epithelial cells. Furthermore, expression of either transcript was up-regulated by blood feeding in larvae and nymphs, suggesting the important roles of legumains in blood feeding and blood-meal digestion in ticks.

• 社団法人日本獣医学会の論文
• 2008-12-25

著者

• Fujisaki Kozo

  Kagoshima Univ. Kagoshima Jpn

• Tsuji Naotoshi

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural Researc

• Fujisaki Kozo

  National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med

• ALIM M.Abdul

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Foo

• MIYOSHI Takeharu

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Foo

• ISLAM M.

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Foo

• HATTA Takeshi

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Foo

• YAMAJI Kayoko

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Foo

• ALIM M.

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agriculture and Food

• Islam M.

  National Agricultural And Food Res. Organization Ibaraki

• Alim M.

  National Agricultural And Food Res. Organization Ibaraki

• Tsuji Naotoshi

  Laboratory Of Parasitic Diseases National Institute Of Animal Health National Agriculture Research O

• Fujisaki Kozo

  National Institute Of Animal Health

• MIYOSHI Takeharu

  National Institute of Animal Health, National Agriculture and Food Research Organization

• Hatta Takeshi

  National Institute Of Animal Health National Agriculture And Food Research Organization

• Islam M.

  Laboratory Of Biochemistry And ** Laboratory Of Protein Chemistry & Engineering Faculty Of Agric

• Yamaji Kayoko

  National Institute Of Animal Health National Agriculture And Food Research Organization

• Tsuji Naotoshi

  National Institute Of Animal Health National Agriculture And Food Research Organization

• Miyoshi Takeharu

  National Institute Of Animal Health National Agriculture And Food Research Organization

• ALIM M.

  Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization

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