Effect of Conduritol A, a Polyol from Gymnema sylvestre, on the Development of Diabetic Cataracts in Streptozotocin-treated Rats and on Aldose Reductase
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概要
- 論文の詳細を見る
Streptozotocin-diabetic rats were maintained on a stock diet for 16 weeks and some were given conduritol A (10mg/kg/day). The administration of conduritol A, having a hypoglycemic effect, markedly prevented the diabetic rats from getting cataracts. In practice, conduritol A inhibited aldose reductase (EC 1.1.1.21) that is capable of catalyzing the conversion of aldoses to sugar alcohols in the polyol pathway. In an in vitro assay, lens aldose reductase was most effectively inhibited by conduritol A when α,β-D-glucose was used as a substrate. Some enzymes from the rats were not inhibited by conduritol A. Neither an intraperitoneal injection nor oral dosage of conduritol A caused acute toxicity in the rats. These findings suggest that the inhibition of lens aldose reductase by conduritol A may be responsible for its cataract-suppressing effect.
- 社団法人日本農芸化学会の論文
- 1994-04-23
著者
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Miyatake K
Osaka Prefecture Univ. Osaka Jpn
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NAKANO Yoshihisa
Graduate School of Life and Environmental Sciences of Osaka Prefecture University
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Nakano Yoshihisa
Graduate School Of Life And Environmental Science Osaka Prefecture University
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Kirihata Mitsunori
Graduate School Of Life And Environmental Science Osaka Prefecture University
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Takenaka S
Department Of Veterinary Sciences Osaka Prefecture University
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Ichimoto Itsuo
Department Of Agricultural Chemistry College Of Agriculture
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Taira T
Osaka Prefecture Univ. Osaka Jpn
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Taira Tomoaki
Department Of Horticulture And Agronomy University Of Osaka Prefecture
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Miyatake Kazutaka
Department Of Agricultural Chemistry University Of Osaka Prefecture
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Takenaka Shigeo
Department Of Mathematics Hiroshima University
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Upadhaya Priya
Department of Agricultural Chemistry, University of Osaka Prefecture
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Nakano Yoshihisa
Department Of Agricultural Chemistry
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Kensho Goro
Department Of Research And Development Dainippon Seito Corp.
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Upadhaya Priya
Department Of Agricultural Chemistry University Of Osaka Prefecture
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Fujimoto Tadashi
Department of Research and Development, Dainippon Seito Corp.
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Noguchi Eriko
Department of Agricultural Chemistry, University of Osaka Prefecture
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Shinohara Makiko
Department of Agricultural Chemistry, University of Osaka Prefecture
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Fujimoto Tadashi
Department Of Research And Development Dainippon Seito Corp.
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Shinohara M
Kyoto Univ. Kyoto Jpn
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Taira Tomoaki
Department of Agricultural Chemistry, University of Osaka Prefecture
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Ichimoto Itsuo
Department of Agricultural Chemistry, University of Osaka Prefecture
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