Stereoselective Synthesis of Unnatural Stereoisomers of LL-P880β and LL-P880γ, Pestalotin Analogues from Penicillium sp.
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概要
- 論文の詳細を見る
A synthesis of unnatural stereoisomers of LL-P880β (2) and subsequent transformation of 2 into LL-P880γ (3) were achieved by starting from diacetoneglucose (4). A chiral building block, 5-deoxy-α-D-ribofuranose derivative 9,was derived from 4 by two synthetic routes. A chiral aldehyde (20) was prepared through a six-step sequence from 9,and treated with the dianion of methyl acetoacetate to complete the synthesis of (6S, 1'R, 2'R)-LL-P880β (2a) and its C_6-epimer (2b). After converting 2a to its diacetate (23), this was transformed into (1'R, 2'R)-LL-P880γ (3a) via a 5-bromopyran derivative (24).
- 社団法人日本農芸化学会の論文
- 1992-11-23
著者
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Miyatake K
Osaka Prefecture Univ. Osaka Jpn
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Kirihata Mitsunori
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Ichimoto I
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture
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Ichimoto Itsuo
Department Of Agricultural Chemistry College Of Agriculture
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Ueda Hiroo
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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OHE Masayuki
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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Ohe Masayuki
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture:institute F
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KIRIHATA Mitsunori
Department of Agricultual Chemistry, College of Agriculture, University of Osaka Prefecture
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