Synthesis of O-[(o-Carboran-1-yl)methyl]-3-hydroxytyrosine, a Novel p-Boronophenyl-alanine Analogue for Boron Neutron Capture Therapy
スポンサーリンク
概要
- 論文の詳細を見る
The synthesis of O-[(o-carboran-1-yl)methyl]-3-hydroxytyrosine (CMHT), a novel o-carborane-containinig amino acid for boron neutron capture therapy, was achieved by the short-step sequence, in which the aldol-type condensation of 4-[(o-carboran-1-yl)-methoxy]benzaldehyde (1) with ethyl isocyanoacetate (2) gave a trans/cis mixture of the oxazolines 5a dnd 5b in a 9:1 ratio. Separated trans-oxazoline 5a was transformed into Syn-CMHT in a moderate yield.
- 社団法人日本農芸化学会の論文
- 1996-01-23
著者
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KIRIHATA Mitsunori
Department of Agriculture, Osaka Prefectural University
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Miyatake K
Osaka Prefecture Univ. Osaka Jpn
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ICHIMOTO Itsuo
Department of Agricultural Chemistry, Faculty of Agriculture, University of Osaka Prefecture
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MATSUDA Kazuhiko
Laboratory of Plant Pathology and Biotechnology and Laboratory of Pesticide Chemistry
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切畑 光統
大阪府立大学 農学部
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Kirihata Mitsunori
Graduate School Of Life And Environmental Science Osaka Prefecture University
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Kirihata Mitsunori
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Ichimoto I
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture
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Ichimoto Itsuo
Department Of Agricultural Chemistry College Of Agriculture
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Morimoto T
Department Of Applied Biological Chemistry The University Of Tokyo
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MORIMOTO Tsuguhiro
Department of Applied Biochemistry, College of Agriculture, University of Osaka Prefecture
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KOBAYASHI Mitsue
Research Reactor Institute of Kyoto University
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KITAOKA Yoshinori
Research Reactor Institute of Kyoto University
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Morimoto T
Kagawa Univ. Kagawa Jpn
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Morimoto Tsuguhiro
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture
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KIRIHATA Mitsunori
Department of Agricultual Chemistry, College of Agriculture, University of Osaka Prefecture
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