Effects of Sugar Acids on the Functions of Ribulose Bisphosphate Carboxylase/Oxygenase : Differentiation of Two Different Ligand-binding Modes of the Catalytic Sites

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概要

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• The effects of sugar acids on the kinetics and the protein conformation of ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) were examined to differentiate the ligand-binding modes of the catalytic sites. D-Glucarate, L-glucarate, and mucate inhibited the carboxylase activity of RuBisCO competitively with respect to ribulose 1, 5-bisphosphate. Their inhibition constants were 2. 5 to 8. 5 m_M. The sugar acids induced such a change of the protein conformation of activated RuBisCO as is detected with a hydrophobic fluorescence probe. However, the change was not concerned with hysteresis of the enzyme. The sugar acids bound to the catalytic sites retarded the release of activator CO_2 from the sites in the absence of CO_2. These characteristics of the sugar acids were quite similar to those of 6-phosphogluconate, but not of fructose bisphosphate or 3-phosphoglycerate. It is proposed that sugar phosphates that bind to the catalytic sites of RuBisCO could be divided into two groups on the basis of the modes of the binding to the sites.

• 社団法人日本農芸化学会の論文
• 1993-01-23

著者

• KIRIHATA Mitsunori

  Department of Agriculture, Osaka Prefectural University

• Yokota A

  Department Of Agricultural Chemistry University Of Osaka Prefecture

• Yokota Akiho

  Department Of Agricultural Chemistry University Of Osaka Prefecture

• ICHIMOTO Itsuo

  Department of Agricultural Chemistry, Faculty of Agriculture, University of Osaka Prefecture

• Kirihata Mitsunori

  Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture

• Kirihata Mitsunori

  Department Of Agricultural Chemistry University Of Osaka Prefecture

• Ichimoto Itsuo

  Department Of Agricultural Chemistry College Of Agriculture

• Izukawa Tatsuya

  Department of Agricultural Chemistry, University of Osaka Prefecture

• Izukawa T

  Ibaraki Univ. Ibaraki Jpn

• KIRIHATA Mitsunori

  Department of Agricultual Chemistry, College of Agriculture, University of Osaka Prefecture

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