Stereoselective Synthesis of Marine Antibiotic (-)-Malyngolide and Its Stereoisomers(Organic Chemistry)
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概要
- 論文の詳細を見る
A convenient synthetic method for the marine antibiotic (-)-malyngolide and its stereoisomers was accomplished from a chiral α-alkoxyketone (4), which was readily available as a chiron. Chiral quaternary carbon synthons (5a) and (5b) as the key intermediates were constructed by the chelation controlled addition of Grignard reagent to 4. The diastereomeric mixture of 5a and 5b was readily transformed into a separable mixture of lactones (7a) and (7b), each of which could be easily separated by silica-gel column chromatography. (-)-Malyngolide and its three steroisomers were obtained in optically pure form without the need for optical resolution.
- 社団法人日本農芸化学会の論文
- 1990-03-23
著者
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Miyatake K
Osaka Prefecture Univ. Osaka Jpn
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Kirihata Mitsunori
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Ichimoto I
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture
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Ichimoto Itsuo
Department Of Agricultural Chemistry College Of Agriculture
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Ueda Hiroo
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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MACHIYA Kozo
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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Machiya Kozo
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture:(present
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KIRIHATA Mitsunori
Department of Agricultual Chemistry, College of Agriculture, University of Osaka Prefecture
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