α2-Adrenoceptor-Mediated Antisecretory Effect of Hypoxia in Conscious Rats

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概要

• 論文の詳細を見る

• Gastric acid secretion is suppressed, resulting in a significant rise in gastric pH, when conscious rats are exposed to hypoxia (Yamaji et al., 1996). When adrenal medullectomized rats ware exposed to moderate (10.5% O_2) hypoxia for 3 h, gastric acid secretion was restored to nearly the level in normoxia by the adrenal medullectomy. In severe (7.6% O_2) hypoxia, the operation also caused an increase in the level of gastric acid output, although the extent was lower than that under 10.5% 0_2 hypoxic conditions. Gastric pH was normalized by the operation even with 7.6% O_2 hypoxia. Similar results were obtained when reserpine, which causes an adrenergic discharge, was administered. When an α2-adrenoceptor blocking agent, yohimbine, was administered, the inhibitory effect of 10.5% and 7.6% O_2 hypoxia on gastric acid secretion was almost completely removed. However, neither prazosin (an α1-adrenoceptor blocker) nor propranolol (a β-adrenoceptor blocker) showed any significant effects on gastric acid output in hypoxia. These results indicate that acute hypoxia simulated the adrenergic response from the adrenal medulla, and that gastric acid secretion was consequently suppressed through α2-adrenoceptor.

• 社団法人日本農芸化学会の論文
• 1998-03-23

著者

• INUI Hiroshi

  Department of Applied Biological Chemistry, Graduate School of Life and Environmental Sciences, Osak

• NAKANO Yoshihisa

  Department of Applied Biological Chemistry, Graduate School of Life and Environmental Sciences, Osak

• YAMAJI Ryoichi

  Department of Applied Biological Chemistry, Graduate School of Life and Environmental Sciences, Osak

• Nakano Y

  Dep. Of Applied Biological Chemistry Graduate School Of Life And Environmental Sciences Osaka Prefec

• Miyatake K

  Osaka Prefecture Univ. Osaka Jpn

• Inui H

  Center For Res. And Dev. Of Bioresources Osaka Prefecture Univ.

• Inui H

  Tottori Univ. Tottori Jpn

• Inui Hiroshi

  Department Of Agricultural Biochemistry And Biotechnology Tottori University:(present Address)depart

• Inui Hiroshi

  Department Of Applied Biological Chemistry Osaka Prefecture University

• Inui Hiroshi

  Department Of Agricultural Biochemistry And Biotechnology Tottori University

• Inui Hiroshi

  Graduate School Of Life And Environmental Sciences Of Osaka Prefecture University

• Yamaji Ryoichi

  Department Of Applied Biological Chemistry Graduate School Of Life And Environmental Sciences Osaka

• WATANABE Fumio

  Department of Architectural Engineering, Kyoto University

• Tsuyama Shingo

  Department of Veterinary Science, Osaka Prefecture University

• NAKANO Yoshihisa

  Graduate School of Life and Environmental Sciences of Osaka Prefecture University

• TAKENOSHITA Makoto

  Department of Applied Biological Chemistry, Osaka Prefecture University

• MIYATAKE Kazutaka

  Department of Applied Biological Chemistry, Osaka Prefecture University

• MATSUDA Kazuhiko

  Laboratory of Plant Pathology and Biotechnology and Laboratory of Pesticide Chemistry

• OHNISHI Yasuyo

  Department of Applied Biological Chemistry, Osaka Prefecture University

• SAKAMOTO Miki

  Department of Applied Biological Chemistry, Osaka Prefecture University

• OHTA Mitsuaki

  Department of Veterinary Physiology, Osaka Prefecture University

• Nakano Yoshihisa

  Graduate School Of Life And Environmental Science Osaka Prefecture University

• Nakano Yoshihisa

  Department Of Agriculture University Of Osaka Prefecture

• 切畑 光統

  大阪府立大学 農学部

• Kirihata Mitsunori

  Graduate School Of Life And Environmental Science Osaka Prefecture University

• Ohnishi Y

  Department Of Biotechnology The University Of Tokyo

• Ohta Mitsuaki

  Department Of Veterinary Physiology Osaka Prefecture University

• Sakamoto Miki

  Department Of Applied Biological Chemistry Osaka Prefecture University

• Takenaka S

  Department Of Veterinary Sciences Osaka Prefecture University

• Tsuyama Shingo

  Department Of Biochemistry School Of Medicine Keio University

• Miyatake Kazutaka

  Department Of Agricultural Chemistry University Of Osaka Prefecture

• Takenoshita Makoto

  Department Of Applied Biological Chemistry Osaka Prefecture University

• Takenoshita Makoto

  Department Of Anesthesiology Shiga University Of Medical Science

• Ohta Mitsuaki

  Department Of Animal Science And Biotechnology Azabu University Graduate School Of Veterinary Medici

• Nakano Yoshihisa

  Department Of Agricultural Chemistry

• Watanabe Fumio

  Department Of Agricultural Chemistry University Of Osaka Prefecture

• Toyoshima Shigeki

  Laboratory Of Nutrition And Food Science Hagoromo-gakuen College

• Ohta Mitsuaki

  Department Of Animal Science And Biotechnology Azabu University

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