An Efficient Synthesis of (±)-α-Kainic Acid Using a 3-Hydroxyallylglycine Derivative as a Common Building Block(Organic Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
(+_-)-α-Kainic acid (1) was synthesized by starting from a building block, N-Boc-3-acetoxyallylglycine ethyl ester (2). The key intermediate, a methyl 4-[(tert-butoxycarbonyl)prenylamino]-5-hydroxy-2-pentenoate derivative (9), was prepared from 2 in eight synthetic steps. After converting 10 into a methyl ester (11), intramolecular ene-carbocyclization of 11 gave a pyrrolidine derivative (12), which was converted to 1 in a moderate yield.
- 社団法人日本農芸化学会の論文
- 1991-12-23
著者
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Kirihata Mitsunori
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Ichimoto Itsuo
Department Of Agricultural Chemistry College Of Agriculture
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KAZIWARA Takeshi
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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KAWASHIMA Yasuko
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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Kawashima Yasuko
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Kaziwara Takeshi
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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KIRIHATA Mitsunori
Department of Agricultual Chemistry, College of Agriculture, University of Osaka Prefecture
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