Asymmetric Synthesis of Optically Pure L-p-Boronophenylalanine by a Hybrid Process
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概要
- 論文の詳細を見る
Optically pure L-p-boronophenylalanine (BPA) was synthesized by a hybrid process involving enantioselective alkylation and subsequent enzymatic hydrolysis. Lithiated (2R)-(-)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine was reacted with 4-bromo-methylbenzeneboronate (2) to yield adduct 4 in a 74% e.e. Stepwise treatment of 4 with hydrochloric acid gave L-BPA methyl ester 6, which was hydrolyzed with chymotrypsin to furnish optically pure L-BPA.
- 社団法人日本農芸化学会の論文
- 1996-04-23
著者
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Kirihata Mitsunori
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture
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Kirihata Mitsunori
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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MORIMOTO Tsuguhiro
Department of Applied Biochemistry, College of Agriculture, University of Osaka Prefecture
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NAKAO Hidekazu
Department of Applied Biochemistry, College of Agriculture, University of Osaka Prefecture
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Morimoto Tsuguhiro
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture
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Nakao Hidekazu
Department Of Applied Biochemistry College Of Agriculture University Of Osaka Prefecture
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KIRIHATA Mitsunori
Department of Agricultual Chemistry, College of Agriculture, University of Osaka Prefecture
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