Effects of Salt Loading on Glomeruli in the Remnant Kidney Model
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概要
- 論文の詳細を見る
The purpose of the present study was to determine whether or not salt excess might increase systemic blood pressure, proteinuria, and progress glomerulosclerosis based on morphometric image analysis in the subtotally nephrectomized rats. Experiments were performed on twelve 6-week-old male Wistar rats weighing 200-250 g. Eight rats received 5/6 nephrectomy and after surgery, these rats were divided into the following 2 groups consisting of 4 rats each: Sham-operation group was given standard water without salt to drink and salt treatment group was given 1% NaCl solution to drink for two weeks. In this remnant kidney model, salt loading was slightly effective in elevating blood pressure and induced significant increases in urinary protein excretion and urinary volume and enhanced glomerular sclerosis. The present results suggest that in the early stage of rat remnant kidney model, salt loading accelerates glomerular alterations with renal dysfunction.
- 日本毒性病理学会の論文
- 1999-12-01
著者
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KUSAKABE Manami
Toxicology Lab., Mitsubishi Pharm.
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Mutai M
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
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Mutai Mamoru
First Department Of Pathology Nagoya City University Medical School
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Mutai Mamoru
Toxicology Laboratory Yokohama Research Center Mitsubishi Chemical Corporation.
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Sugimoto Jiro
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
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Sugimoto Jirou
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
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Okada Miyoko
Safety Research Laboratory (Kazusa), Mitsubishi Tanabe Pharma Corporation
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Kusakabe Manami
Toxicology Lab. Mitsubishi Pharm.
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Sugimoto Jiro
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
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Okada Miyako
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
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Okada Miyoko
Mitsubishi-tokyo Pharmaceuticals Incorporation Yokohama Research Center Pharmacokinetics And Toxicol
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Mutai Mamoru
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
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SUGIMOTO Jiro
Mitsubishi-Tokyo Pharmaceuticals, Incorporation, Yokohama Research Center, Pharmacokinetics and Toxi
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UMEDA Asami
Mitsubishi-Tokyo Pharmaceuticals, Incorporation, Yokohama Research Center, Pharmaceuticals Research
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KUSAKABE Manami
Mitsubishi-Tokyo Pharmaceuticals, Incorporation, Yokohama Research Center, Pharmacokinetics and Toxi
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WAZAKI Masahiko
Mitsubishi-Tokyo Pharmaceuticals, Incorporation, Yokohama Research Center, Pharmacokinetics and Toxi
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MUTAI Mamoru
Mitsubishi-Tokyo Pharmaceuticals, Incorporation, Yokohama Research Center, Pharmacokinetics and Toxi
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Umeda Asami
Mitsubishi-tokyo Pharmaceuticals Incorporation Yokohama Research Center Pharmaceuticals Research Lab
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Wazaki Masahiko
Mitsubishi-tokyo Pharmaceuticals Incorporation Yokohama Research Center Pharmacokinetics And Toxicol
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