The Effect of 5α-Dihydrocortisol on the Blood Pressure of Rats Treated with Deoxycorticosterone Acetate and Salt
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概要
- 論文の詳細を見る
5α-dihydrocortisol has been reported to amplify the mineralocorticoid activity of aldosterone. In this study 5α-dihydrocortisol was administered to unilaterally nephrectomized rats treated with 11-deoxcorticosterone acetate (DOCA) and sodium chloride to examine its potentiating effect on the elevation of blood pressure in these animals. Subcutaneous administration of DOCA at two dose levels (40μg and 100μg/100g of body weight 3 times a week) resulted in a significant rise in blood pressure when compared with controls given no DOCA. However, concomitaut injection of 5α-dihydrocortisol (300μg/100 g of body weight 3 times a week) with both doses of DOCA did not accelerate the development or potentiate the severity of the hypertension in a 4 week period. Furthermore, administration of 5α-dihydrocorlisol did not cause a further decrease in plasma renin activity or a greater increase in urinary kallikrein excretion than those observed after DOCA alone. Thus, 5α-dihydrocortisol does not potentiate DOCA in the production of low renin hypertension in unilaterally nephrectomized salt-loaded rats.
- 社団法人 日本内分泌学会の論文
著者
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Ogihara Toshio
Department Of Geriatic Medicine
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Mikami Hiroshi
Department Of Community Health Nursing Osaka University Graduate School Of Medicine
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Mikami Hiroshi
Department Of Geriatric Medicine Osaka University Medical School
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NAKA TORU
Department of Medicine and Geriatrics, Osaka University Medical School
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Naka Toru
Department Of Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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Iwanaga Keiichi
Departmentof Medicine And Geriatrics Osaka University Medical School
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NUGENT CHARLES
The Endocrine Section, Department of Internal Medicine, University of Arizona, College of Medicine
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IWANAGA KEIICHI
Department of Medicine and Geriatrics, Osaka University Medical School
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