The Role of Antihypertensive Polar Renomedullary Lipid in the Pathogenesis of Hypertension : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES
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概要
- 論文の詳細を見る
One-0-hexadecyl-2-0-acetyl-sn-glycero-3-phosphorylcholine (HAGPC), a component of semisynthetic antihypertensive polar renomedullary lipid (APRL) reported by Muirhead et al. in chemically treated rabbit renomedullary lipid had a strong hypotensive action, a cardiosuppressing action and an apparent anti-norepinephrine action. 3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl-2-thiazolioethyl phosphate significantly inhibited the hypotensive action of HAGPC, whereas the hypotensive activities of prostaglandin I_2, prostaglandin E_2, bradykinin, histamine and acethylcholine were not affected by this drug. The blood pressure of rats with established hypertension produced by clipping one renal artery and contralateral nephrectomy normally decreases rapidly after unclipping the renal artery, but the initial rapid decrease was significantly inhibited by an intravenous infusion of 3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl-2-thiazolioethyl phosphate. This shows that endogenous 1-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine participates in the rapid decrease of blood pressure after unclipping the renal artery in one-kidney, one clip hypertensive rats.
- 社団法人日本循環器学会の論文
- 1984-02-20
著者
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OGIHARA Toshio
Department of Geriatric Medicine, Osaka University Graduate School of Medicine
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Ogihara Toshio
Department Of Geriatic Medicine
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Kumahara Yuichi
Department of Medicine and Geriatrics, Osaka University Medical School
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KUMAHARA YUICHI
The Department of Medicine and Geriatrics, Osaka University Medical School
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Otsuka Atsuhiro
Department of Geriatric Medicine, Osaka Univ. Med. Sch.
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Otsuka Atsuhiro
Osaka University Medical School
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Masugi Fuminori
Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku. Osaka 55 3 Jap
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Saeki Shuichi
Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku. Osaka 55 3 Jap
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Saeki Shuichi
Department Of Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
The Department Of Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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Masugi Fuminori
Department Of Medicine And Gerictrics Osaka University Medical School
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Otsuka Atsuhiro
Department Of Geriatric Medicine Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Geriatrics Osaka University Medical School:sakurabashi Watanabe Hospital
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Kumahara Y
Department Of Medicine And Geriatrics Osaka University Medical School:sakurabashi Watanabe Hospital
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Kumahara Yuichi
The Central Laboratory For Clinical Investigation Osaka Univ. Hosp. Osaka And The Center For Adult D
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