Effects of an angiotensin II antagonist; [sarcosine, isoleucine] angiotensin II, on blood pressure, plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive subjects taking oral contraceptives.
スポンサーリンク
概要
- 論文の詳細を見る
To examine the involvement of renin-angiotensin-aldosterone system in the etiology of oral contraceptive induced hypertension, normal women (Group I), normotensive (Group II) and hypertensive (Group III) women taking Ovulen (R) were infused with a competitive angiotensin II (AII) antagonist, [1-sarcosine, 8-isoleucine] angiotensin II. The angiotensin II antagonist was infused at a rate of 600ng/kg/min for 30min 1.5hrs after intravenous injection of40mg of furosemide. Blood pressure was monitored and pre-infusion and post-infusion plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were determined.<BR>Pre-infusion PRA and PAC showed no significant differences among these three groups. In response to the AII antagonist infusion blood pressure rose in Groups and II, but blood pressure responses in Group III were variable. Four out of the total 6 subjects had pressor responses and only one subject had a significant blood pressure reduction. In both Groups I and II, PRA decreased and PAC rose after infusion of the antagonist. In Group III, PRA decreased to a lesser degree and PAC showed no consistent change. These data suggest that the renin-angiotensinaldosterone system in hypertensive women or oral contraceptives is different from that of the normotensive users. However, the pathophysiology of oral contraceptive induced hypertension is not homogenous and angiotensinogenic hypertension is uncommon.
- 社団法人 日本内分泌学会の論文
著者
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Ogihara Toshio
Department Of Geriatic Medicine
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Hata Takeshi
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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Mikami Hiroshi
Department Of Community Health Nursing Osaka University Graduate School Of Medicine
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Nakamaru Mitsuaki
Department of Ceriatric Medicine, Osaka University Medical School
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Maruyama Anna
Departmentof Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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MIKAMI HIROSHI
Department of Medicine and Geriatrics, Osaka University Medical School
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HATA TAKESHI
Department of Medicine and Geriatrics, Osaka University Medical School
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NAKAMARU MITSUAKI
Department of Medicine and Geriatrics, Osaka University Medical School
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MARUYAMA ANNA
Department of Medicine and Geriatrics, Osaka University Medical School
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MARUYAMA ANNA
Department of Medicine and Geriatrics, Osaka University
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OGIHARA TOSHIO
Department of Medicine and Geriatrics, Osaka University Medical School
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