Effect of a Single Dose of Glucocorticoid on the Diurnal Variations of TSH, Thyroxine, 3, 5, 3-triiodothyronine, 3, 35-triiodothyronine and Cortisol in Normal Men
スポンサーリンク
概要
- 論文の詳細を見る
Plasma thyrotropin (TSH) and cortisol concentrations were suppressed immediatelyafter an intravenous bolus dose of8mg betamethasone in 6 male subjects. The circadian variations of these hormones disappeared for40hr (TSH) and44hr (cortisol). Plasma thyroxine (T<SUB>4</SUB>), 3, 5, 3-triiodothyronine (T<SUB>3</SUB>), 3, 3, 5-triiodothyronine (reverse T<SUB>3</SUB>) levels did not show diurnal variations before betamethasone administration. Plasma T<SUB>3</SUB>levels decreased to 66% of the basal levels 20hr after batamethasone administration, whereas plasma reverse T<SUB>3</SUB>levels increased to163% of the basal levels at 24hr. These changes were reversed by3to5days after betamethasone. Theearlier recovery of the diurnal rhythm of TSH than that of cortisolsuggests thatthe TSH rhythm is not under the direct control of circulating cortisol.
- 社団法人 日本内分泌学会の論文
著者
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AZUKIZAWA Mizuo
Clinical Pathology Osaka University Hospital
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Azukizawa Mizuo
Department of Clinical Pathology,Osaka University Hospital
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Miyai Kiyoshi
The Central Laboratory For Clinical Investigation And The First Department Of Medicine Osaka Univers
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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Ohta Hiroshi
Department Od Cardiovascular Medicine Juntendo University
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MORI SHINTARO
The Central Laboratory for Clinical Investigation, Osaka University Hospital
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MATSUMURA SHIGEJIRO
The Central Laboratory for Clinical Investigation, Osaka University Hospital
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YOSHIMOTO HISANORI
The Central Laboratory for Clinical Investigation, Osaka University Hospital
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UOZUMI TORU
The Central Laboratory for Clinical Investigation, Osaka University Hospital
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AZUKIZAWA Mizuo
Department of Medicine and Geriatrics, Osaka University Hospitall
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