Relation Between Pituitary Responsiveness to Thyrotropin Releasing Hormone and Serum Thyroid Hormones in Hyperthyroidism
スポンサーリンク
概要
- 論文の詳細を見る
Seventy-five TRH tests were carried out in 61 subjects with hyperthyroidism before and in the course of treatment; the results were correlated with serum T<SUB>4</SUB> and T<SUB>3</SUB> concentrations. In certain subjects, T<SUB>3</SUB> suppression tests were done along with the TRH test. All subjects with elevated T4 and T<SUB>3</SUB> (group 1) did not show a TSH response to TRH. Eleven out of 13 subjects with normal T<SUB>4</SUB> and elevated T<SUB>3</SUB> (group 2) did not show TSH response. In 22 subjects with normal T<SUB>4</SUB> and T<SUB>3</SUB> (group 3), 40.9%(9/22) did respond and 59.1%(13/22) did not respond to TRH. In 7 subjects with low T<SUB>4</SUB> and/or T<SUB>3</SUB> (group 4), 4 did not respond and 3 did respond to TRH. In each group, there were no significant differences in age and sex of the subjects, mode of therapy, serum thyroid hormones (T<SUB>4</SUB>, T<SUB>3</SUB>) and BMR between responders and non-responders to TRH. Sixteen subjects underwent T<SUB>3</SUB> suppression tests. Twelve subjects with no or low TSH response to TRH did not show suppression, while all 4 subjects with normal or exaggerated TSH response showed suppression. The results indicate that serum thyroid hormone levels are not the sole determinant of the TSH response to TRH and confirm that the suppressibility of the thyroid gland by T<SUB>3</SUB> appears to require the presence of sufficient TSH secretion from the pituitary. Several mechanisms of variable TSH response to TRH in the course of treatment of hyperthyroidism were discussed.
- 社団法人 日本内分泌学会の論文
著者
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AZUKIZAWA Mizuo
Clinical Pathology Osaka University Hospital
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Miyai Kiyoshi
Central Laboratory For Clinical Investigation And Department Of Laboratory Medicine Osaka University
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Kumahara Yuichi
Central Laboratory For Clinical Investigation Osaki University Hospital
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AZUKIZAWA Mizuo
Central Laboratory for Clinical Investigation, Second Department of Surgery
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YAMAMOTO TOSHIHIDE
Central Laboratory for Clinical Investigation, Osaka University Medical School
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KUMAHARA YUICHI
Central Laboratory for Clinical Investigation, Osaka University Medical School
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AZUKIZAWA Mizuo
Central Laboratory for Clinical Investigation, Osaka University Hosbital
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AZUKIZAWA MIZUO
Central Laboratory for Clinical Investigation, Osaka University Medical School
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