Dual Effect of Clomiphene Citrate on Pituitary Gonadotropin Secretion in Postmenopausal Women
スポンサーリンク
概要
- 論文の詳細を見る
Fifteen postmenopausal women were given 25mg, 50mg of clomiphene citrate daily by mouth for 3 consecutive days. Significant (p<0.01) decrease of serum LH (73%, 65%) and FSH (76%, 76%) resulted after administration of 25mg and 50mg clomiphene citrate respectively. The suppressive effect was sustained for at least 4 days after cessation of this drug.<BR>On the other hand decreased LH and FSH levels after administration of ethinyl estradiol increased again by simultaneous administration of clomiphene citrate. These results suggest that estrogenic effects of clomiphene citrate are observed in untreated estrogen deficient subjects but anti-estrogenic effects are evident when serum estrogen levels are restored in subjects with estrogen deficiency.
- 社団法人 日本内分泌学会の論文
著者
-
Miyai Kiyoshi
The Central Laboratory For Clinical Investigation And The First Department Of Medicine Osaka Univers
-
Kumahara Yuichi
The Central Laboratory For Clinical Investigation And The First Department Of Medicine Osaka Univers
-
HASHIMOTO TAKUMA
The Central Laboratory for Clinical Investigation, Osaka University Medical School
-
IZUMI KANJI
The Department of Internal Medicine, National Osaka Hospital
-
ONISHI TOSHIO
The Central Laboratory for Clinical Investigation, Osaka University Medical School
-
MIYAI KIYOSHI
The Central Laboratory for Clinical Investigation, Osaka University Medical School
関連論文
- CLINICAL APPLICATIONS OF SYNTHETIC ANGIOTENSIN II ANALOGUE
- Suppression of Thyroid Function during Ingestion of Seaweed "Kombu" (Laminaria japonoca) in Normal Japanese Adults
- Radioimmunoelectrophoretic Analysis of Thyroid Hormone Binding Proteins in Normal Human Sera
- Effect of a Single Dose of Glucocorticoid on the Diurnal Variations of TSH, Thyroxine, 3, 5, 3-triiodothyronine, 3, 35-triiodothyronine and Cortisol in Normal Men
- Transient Hypothyroidism Associated with Increased Anti-microsomal Antibodies
- Dual Effect of Clomiphene Citrate on Pituitary Gonadotropin Secretion in Postmenopausal Women
- Plasma Renin Activity and Aldosterone Concentration of Patients with Hyperthyroidism and Hypothyroidism