Comparison of Two Angiotensin II Analogues in Normal Subjects and Hypertensive Patients
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概要
- 論文の詳細を見る
Two angiotensin II analogues, <I>i. e</I>., 1-sarcosine, 8-isoleucine angiotensin II (Sar<SUP>1</SUP>, Ile-AII) and 1-sarcosine, 8-alanine angiotensin II (Sar<SUP>1</SUP>, Ala<SUP>8</SUP>-AII), are now available in the clinical study. Comparative studies of the antagonistic potency and the agonistic effect of these two AII analogues were made in normal subjects on three soidum balances and in hypertensive patients with various etiologies on sodium depletion. Both AII analogues had an agonistic pressor effect in normal subjects. This effect changed with different sodium balances. In the low sodium state, this agonistic action was minimized. The agonistic pressor effect of Sar<SUP>1</SUP>, IIe<SUP>8</SUP>-AII was greater than that of Sar<SUP>1</SUP>, Ala<SUP>8</SUP>-AII in all sodium states. There was found an agonistic activity of both AII analogues not only on blood pressure, but also on renin and aldosterone secretion, and renal vasculature in normal subjects on a regular diet. The antagonistic depressor potency of both compounds was also varied by changing sodium balance, being greatest in the low sodium state. In hypertensive patients on sodium depletion, the blood pressure responses of individual patients to these two AII analogues were significantly correlated (r=0.8, n=20). These results indicate that pretreatment of sodium depletion is necessary to prevent the side effect caused by the agonistic pressor action of AII analogue, and also to predict renin dependency in hypertensive patients efficiently.
- 社団法人 日本内分泌学会の論文
著者
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Ogihara Toshio
Department Of Geriatic Medicine
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Hata Takeshi
Department Of Medicine And Geriatrics Osaka University Medical School
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Hata Takeshi
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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Mikami Hiroshi
Department Of Community Health Nursing Osaka University Graduate School Of Medicine
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Nakamaru Mitsuaki
Department of Ceriatric Medicine, Osaka University Medical School
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MANDAI Takashi
Department of Medicine and Geriatrics,Osaka University Medical School
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Maruyama Anna
Departmentof Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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Mandai Takashi
Department Of Medicine And Geriatrics Osaka University Medical School
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MANDAI TAKASHI
Department of Medicine and Geriatrics, Osaka University Medical School
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