Blood pressure response to an angiotensin II antagonist in thyrotoxic patients with and without high blood pressure.
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概要
- 論文の詳細を見る
An angiotensin II antagonist, [sacrosine, isoleucine] angiotensin II, was infused into thyrotoxic patients. Blood pressure was monitored before and during the infusions to investigate whether the renin-angiotensin-aldosterone system was involved in the maintenance of blood pressure in normotensive and hypertensive thyrotoxic patients.<BR>Five out of 17 normotensive patients with hyperthyroidism showed more than a 10 mmHg decrease in mean blood pressure in response to the infusion (responders), while the remaining 12 patients showed no substantial change in blood pressure (non-responders). The infusion caused little change in blood pressure in 8 hyperthyroid patients with systolic hypertension. The mean levels of serum thyroxine, triiodothyronine, plasma renin activity and plasma aldosterone concentralion in the normotensive responders were significantly higher than the values in the normotensive non-responders. There were no significant differences in these laboratory values between the hypertensive patients and the normotensive non-responders except that serum triiodothyronine levels were significantly higher in the hypertensive patients.<BR>The present study indicates that increased activity of the renin-angiotensinaldosterone system is involved in the maintenance of blood pressure in most normotensive patients with severe hyperthyroidism, while hypertension in patients with hyperthyroidism is not angiotensin II dependent.
- 社団法人 日本内分泌学会の論文
著者
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Ogihara Toshio
Department Of Geriatic Medicine
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Hata Takeshi
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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Mikami Hiroshi
Department Of Community Health Nursing Osaka University Graduate School Of Medicine
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KUMA Kanji
Kuma Hospital
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Nakamaru Mitsuaki
Department of Ceriatric Medicine, Osaka University Medical School
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Naka Toru
Department Of Medicine And Geriatrics Osaka University Medical School
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Maruyama Anna
Departmentof Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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NAKA TORU
Department of Medicine and Geriatrics, Osaka University
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MIKAMI HIROSHI
Department of Medicine and Geriatrics, Osaka University
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HATA TAKESHI
Department of Medicine and Geriatrics, Osaka University
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NAKAMARU MITSUAKI
Department of Medicine and Geriatrics, Osaka University
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MARUYAMA ANNA
Department of Medicine and Geriatrics, Osaka University
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