Heterogeneity of Plasma and Urinary Immunoreactive Calcitonin in Patients with Medullary Carcinoma of the Thyroid
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概要
- 論文の詳細を見る
The immunological heterogeneity of calcitonin (CT) was examined in fractions separated by gel filtration (Bio Gel P-30) from plasma and urine samples of two patients with medullary carcinoma of the thyroid obtained after calcium infusion and after thyroidectomy. Five distinct forms of immunoreactive CT were observed bygel filtration of plasma before treatment; one was eluted with the monomer CT and the other four were of higher molecular weight. The concentrations of all fiveforms increased during calcium infusion (4mg/kg, 10min) and decreased after the infusion, accompanied by a rapid change in concentration of the monomer form. After thyroidectomy, the level of the monomer form decreased faster than the levels of other forms. The main form in the urine was eluted in the same portion as abigger form (IIIb) in the plasma, not with the monomer form, after throidectomy.One antiserum (antiserum I) gave a higher estimation for the IIIb form and the predominant form in the urine than another antiserum (antiserum II). These findings suggest the identity of these two forms. Blood CT in various forms, including the monomer, may be converted to form IIIb in the kidney and exreted in that form.
- 社団法人 日本内分泌学会の論文
著者
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Onishi Toshio
Department Of Fisheries Faculty Of Agriculture Tohoku University
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Morimoto Shigeto
Department Of Geriatric Medicine Graduate School Of Medicine Osaka University
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Morita Satoshi
Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate
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Mori Shintaro
Department Of Neurosurgery Osaka University Hospital
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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Okada Yoshiaki
Department Of Bacterial And Blood Products National Institute Of Infectious Diseases
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Miyauchi Akira
Second Department Of Surgery Kagawa Medical School
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LEE SHOUSHI
Department of Medicine and Geriatrics, Osaka University Medical School
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TAKAI SHIN-ICHRO
Second Department of Surgery, Osaka University Medical School
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NISHIOKA YOSHIKUNI
Department of Medicine and Geriatrics, Kagawa Medical School
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Morimoto Shigeto
Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate
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KUMAHARA YUICHI
Department of Medicine and Geriatrics, Kagawa Medical School
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ONISHI TOSHIO
Department of Medicine and Geriatrics, Kagawa Medical School
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LEE SHOUSHI
Department of Medicine and Geriatrics, Kagawa Medical School
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MORIMOTO SHIGETO
Department of Medicine and Geriatrics, Kagawa Medical School
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OKADA YOSHIAKI
Department of Medicine and Geriatrics, Kagawa Medical School
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